Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2

Bongiorno, Daria, Schuetz, Friderike, Poronnik, Philip and Adams, David J. (2011) Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2. Channels, 5 1: 79-88. doi:10.4161/chan.5.1.13967


Author Bongiorno, Daria
Schuetz, Friderike
Poronnik, Philip
Adams, David J.
Title Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2
Journal name Channels   Check publisher's open access policy
ISSN 1933-6950
1933-6969
Publication date 2011-02-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.4161/chan.5.1.13967
Volume 5
Issue 1
Start page 79
End page 88
Total pages 10
Place of publication Austin, TX, United States
Publisher Landes Bioscience
Formatted abstract
The electrical excitability of neurons is mediated primarily by voltage-gated ion channels, particularly voltage-gated Na+ (NaV), K+ (KV) and Cl - (ClC) channels. Cells regulate their electrical excitability by controlling not only the activity, but also the number of individual ion channels in the plasma membrane. There exist several mechanisms for regulating levels of voltage-gated ion channels: transcription and translation, retention and export from the endoplasmic reticulum as well as insertion and retrieval from the plasma membrane. Alterations in voltage-gated ion channel activity, composition and distribution can contribute to the pathophysiology of epilepsy, hypertension, neuropathic and inflammatory pain. One mechanism for retrieval is ubiquitination. Here specific ubiquitin ligases bind to membrane proteins to modulate and regulate their cellular fate. In this review, we focus on Nedd4 and Nedd4-2 ubiquitin ligases and the mechanisms by which they regulate voltage-gated ion channels and describe a novel paradigm on the mechanisms that underpin aberrant ion channel function in neurological disorders.
Keyword Chloride channels
KCNQ channels
Nedd4
Nedd4-2
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Biomedical Sciences Publications
 
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