1α,25-dihydroxyvitamin D3 (vitamin D3) catalyzes suppressive activity on human natural regulatory T cells, uniquely modulates cell cycle progression, and augments FOXP3

Morales-Tirado, Vanessa, Wichlan, David G., Leimig, Thasia E., Street, Shayna E. A., Kasow, Kimberly A. and Riberdy, Janice M. (2011) 1α,25-dihydroxyvitamin D3 (vitamin D3) catalyzes suppressive activity on human natural regulatory T cells, uniquely modulates cell cycle progression, and augments FOXP3. Clinical Immunology, 138 2: 212-221. doi:10.1016/j.clim.2010.11.003


Author Morales-Tirado, Vanessa
Wichlan, David G.
Leimig, Thasia E.
Street, Shayna E. A.
Kasow, Kimberly A.
Riberdy, Janice M.
Title 1α,25-dihydroxyvitamin D3 (vitamin D3) catalyzes suppressive activity on human natural regulatory T cells, uniquely modulates cell cycle progression, and augments FOXP3
Journal name Clinical Immunology   Check publisher's open access policy
ISSN 1521-6616
1521-7035
Publication date 2011-02-01
Sub-type Article (original research)
DOI 10.1016/j.clim.2010.11.003
Volume 138
Issue 2
Start page 212
End page 221
Total pages 10
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Language eng
Abstract Human natural regulatory T cells (nTregs) show great promise for therapeutically modulating immune-mediated disease, but remain poorly understood. One explanation under intense scrutiny is how to induce suppressive function in non-nTregs and increase the size of the regulatory population. A second possibility would be to make existing nTregs more effective, like a catalyst raises the specific activity of an enzyme. The latter has been difficult to investigate due to the lack of a robust short-term suppression assay. Using a microassay described herein we demonstrate that nTregs in distinct phases of cell cycle progression exhibit graded degrees of potency. Moreover, we show that physiological concentrations of 1α,25-dihydroxyvitamin D3 (vitamin D3) boosts nTregs function. The enhanced suppressive capacity is likely due to vitamin D3's ability to uniquely modulate cell cycle progression and elevate FOXP3 expression. These data suggest a role for vitamin D3 as a mechanism for catalyzing potency of nTregs.
Keyword Regulatory T cells
FOXP3
Vitamin D3
Immune regulation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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