Palliative radiotherapy of bone metastases and pain flare

Chow, Edward, Presutti, Roseanna, Hird, Amanda, DeAngelis, Carlo, Fairchild, Alysa, Holt, Tanya and Loblaw, Andrew (2010) Palliative radiotherapy of bone metastases and pain flare. Journal of Pain Management, 4 1: 105-115.

Author Chow, Edward
Presutti, Roseanna
Hird, Amanda
DeAngelis, Carlo
Fairchild, Alysa
Holt, Tanya
Loblaw, Andrew
Title Palliative radiotherapy of bone metastases and pain flare
Journal name Journal of Pain Management   Check publisher's open access policy
ISSN 1939-5914
Publication date 2010-01-01
Year available 2010
Sub-type Article (original research)
Volume 4
Issue 1
Start page 105
End page 115
Total pages 11
Place of publication Hauppauge, NY United States
Publisher Nova Science Publishers, Inc.
Language eng
Subject 2703 Anesthesiology and Pain Medicine
Abstract Radiotherapy is an effective modality for the palliation of symptomatic bone metastases with pain relief experienced by up to 80% of patients. Immediately following irradiation treatment, some patients experience an increase in pain, which is identified as a pain "flare". Approximately forty- percent of patients experience pain flare and can be greatly impacted by this phenomenon. Pain flare may have a debilitating effect on general functioning and quality of life, and the majority of patients prefer prevention of pain flare. Recent research has shown dexamethasone, a corticosteroid, to be an effective prophylactic agent reducing the incidence of pain flare to approximately 20% within a ten-day period following radiation treatment. Despite advances in reducing the incidence of pain flare, the mechanism behind this phenomenon is still largely unknown but may be related to inflammatory cytokines. Research is ongoing on pain flare urinary markers and dexamethasone metabolism to better understand the mechanism and experience of pain flare despite prophylaxis. This paper explores the incidence of pain flare, its impact on patients and the role of dexamethasone prophylaxis. Future investigations are also discussed.
Keyword Cancer
Palliative care
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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