Cylinders vs. spheres: biofluid shear thinning in driven nanoparticle transport

Cribb, Jeremy A., Meehan, Timothy D., Shah, Sheel M., Skinner, Kwan and Superfine, Richard (2010) Cylinders vs. spheres: biofluid shear thinning in driven nanoparticle transport. Annals of Biomedical Engineering, 38 11: 3311-3322. doi:10.1007/s10439-010-0084-5


Author Cribb, Jeremy A.
Meehan, Timothy D.
Shah, Sheel M.
Skinner, Kwan
Superfine, Richard
Title Cylinders vs. spheres: biofluid shear thinning in driven nanoparticle transport
Journal name Annals of Biomedical Engineering   Check publisher's open access policy
ISSN 0090-6964
1573-9686
Publication date 2010-11-01
Sub-type Article (original research)
DOI 10.1007/s10439-010-0084-5
Open Access Status Not Open Access
Volume 38
Issue 11
Start page 3311
End page 3322
Total pages 12
Place of publication New York, United States
Publisher Springer
Abstract Increasingly, the research community applies magnetophoresis to micro and nanoscale particles for drug delivery applications and the nanoscale rheological characterization of complex biological materials. Of particular interest is the design and transport of these magnetic particles through entangled polymeric fluids commonly found in biological systems. We report the magnetophoretic transport of spherical and rod-shaped particles through viscoelastic, entangled solutions using lambda-phage DNA (λ-DNA) as a model system. In order to understand and predict the observed phenomena, we fully characterize three fundamental components: the magnetic field and field gradient, the shape and magnetic properties of the probe particles, and the macroscopic rheology of the solution. Particle velocities obtained in Newtonian solutions correspond to macroscale rheology, with forces calculated via Stokes Law. In λ-DNA solutions, nanorod velocities are 100 times larger than predicted by measured zero-shear viscosity. These results are consistent with particles experiencing transport through a shear thinning fluid, indicating magnetically driven transport in shear thinning may be especially effective and favor narrow diameter, high aspect ratio particles. A complete framework for designing single-particle magnetic-based delivery systems results when we combine a quantified magnetic system with qualified particles embedded in a characterized viscoelastic medium.
Keyword DNA
Drug delivery
Magnetic bead rheology
Microrheology
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 12 times in Thomson Reuters Web of Science Article | Citations
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