Cardiovascular implantable electrophysiological device-related infections: a review

Gould, Paul A., Gula, Lorne J., Yee, Raymond, Skanes, Allan C., Klein, George J. and Krahn, Andrew D. (2011) Cardiovascular implantable electrophysiological device-related infections: a review. Current Opinion in Cardiology, 26 1: 6-11. doi:10.1097/HCO.0b013e328341384e

Author Gould, Paul A.
Gula, Lorne J.
Yee, Raymond
Skanes, Allan C.
Klein, George J.
Krahn, Andrew D.
Title Cardiovascular implantable electrophysiological device-related infections: a review
Journal name Current Opinion in Cardiology   Check publisher's open access policy
ISSN 0268-4705
Publication date 2011-01-01
Year available 2011
Sub-type Article (original research)
DOI 10.1097/HCO.0b013e328341384e
Open Access Status Not yet assessed
Volume 26
Issue 1
Start page 6
End page 11
Total pages 6
Place of publication Philadelphia United States
Publisher Lippincott Williams & Wilkins
Language eng
Abstract Purpose of review
Formatted abstract
Purpose of review: The use of cardiac implantable electrophysiological device (CIED) therapy in the management of cardiac disease is increasing with the improvements in technology of permanent pacemaker and implantable cardioverter defibrillators. Accordingly CIED-related infections are increasing and have become an important clinical problem. The purpose of this review is to summarize current literature on the epidemiology, risk factors, pathophysiology, diagnosis and management of CIED-related infections.

Recent findings: The diagnosis and management of CIED-related infections can be difficult. Recent research would suggest extraction of all CIED components, and concomitant appropriate antibiotic therapy is the principal management modality of CIED component and pocket infection. The exact duration of antibiotic therapy and timing of re-implantation still require further delineation in the absence of comparative evidence; however, improvements in technologies such as the excimer laser have enabled percutaneous extraction to be performed effectively and safely in the vast majority of patients. Differentiating CIED-related infection from noninfected mechanical issues that may not require extraction or antibiotics can be very difficult. Research is continuing into better methods to diagnose and treat infection.

Summary: CIED-related infections are an important clinical problem with ongoing research to improve diagnosis and treatment. Currently, percutaneous CIED extraction and antibiotic therapy are the mainstay of treatment.
Keyword Device
Implantable cardioverter defibrillator
Prosthesis-related infections
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
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