The interplay of the interleukin 1 system in pregnancy and labor

Heng, Yujing Jan, Liong, Stella, Permezel, Michael, Rice, Gregory E., Quinzio, Megan K. W. and Georgiou, Harry M. (2014) The interplay of the interleukin 1 system in pregnancy and labor. Reproductive Sciences, 21 1: 122-130. doi:10.1177/1933719113492204


Author Heng, Yujing Jan
Liong, Stella
Permezel, Michael
Rice, Gregory E.
Quinzio, Megan K. W.
Georgiou, Harry M.
Title The interplay of the interleukin 1 system in pregnancy and labor
Journal name Reproductive Sciences   Check publisher's open access policy
ISSN 1933-7191
1933-7205
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1177/1933719113492204
Open Access Status Not Open Access
Volume 21
Issue 1
Start page 122
End page 130
Total pages 9
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Language eng
Formatted abstract
This work assessed the temporal coexpression of interleukin 1 (IL-1) and its inhibitor, IL-1 receptor antagonist (IL-1ra), in the cervicovaginal fluid (CVF) beyond 24 weeks gestation including women in spontaneous term labor. Two cohorts of women were recruited at 24 to 35 weeks’ gestation (n = 65) and in late pregnancy (>36 weeks’ gestation; n = 88). The CVF was serially collected either every 4 weeks between 24 and 35 weeks’ gestation (n = 123 samples) or weekly during late pregnancy (n = 240 samples). The IL-1 and IL-1ra were quantitated by enzyme-linked immunosorbent assay, and the effect of vaginal microflora and unprotected sexual intercourse were also investigated. The IL-1β and IL-1ra remain unaltered between 24 and 35 weeks’ gestation. At late pregnancy, IL-1α and β concentrations peak at 4 to 14 days prior to labor onset, while IL-1ra decreases with approaching spontaneous term labor (P < .05, 2-way analysis of variance). The IL-1 and IL-1ra were significantly correlated (P < .001, Pearson r). A combined biomarker model of IL-1α, IL-1β, and IL-1ra can predict term labor with 86% sensitivity and 92% specificity. This study indicates a shifting inflammatory balance in the gestational tissues prior to labor onset.
Keyword Cervicovaginal fluid
Interleukin-1
Interleukin-1 receptor antagonist
Labor
Pregnancy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 14 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 14 times in Scopus Article | Citations
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Created: Wed, 27 Nov 2013, 21:56:11 EST by Roheen Gill on behalf of UQ Centre for Clinical Research