Development of magnetic separation system of magnetoliposomes

Nakao, R., Matuo, Y., Mishima, F., Taguchi, T., Maenosono, S. and Nishijima, S. (2009). Development of magnetic separation system of magnetoliposomes. In: Proceedings of the 21st International Symposium on Superconductivity (ISS 2008). ISS 2008: 21st International Symposium on Superconductivity, Tsukuba, Japan, (1840-1844). 27–29 October, 2008. doi:10.1016/j.physc.2009.05.244


Author Nakao, R.
Matuo, Y.
Mishima, F.
Taguchi, T.
Maenosono, S.
Nishijima, S.
Title of paper Development of magnetic separation system of magnetoliposomes
Conference name ISS 2008: 21st International Symposium on Superconductivity
Conference location Tsukuba, Japan
Conference dates 27–29 October, 2008
Proceedings title Proceedings of the 21st International Symposium on Superconductivity (ISS 2008)   Check publisher's open access policy
Journal name Physica C: Superconductivity and its Applications   Check publisher's open access policy
Place of Publication Amsterdam, Netherlands
Publisher Elsevier North-Holland
Publication Year 2009
Year available 2008
Sub-type Fully published paper
DOI 10.1016/j.physc.2009.05.244
Open Access Status Not Open Access
ISSN 0921-4534
1873-2143
Volume 469
Issue 15-20
Start page 1840
End page 1844
Total pages 5
Language eng
Formatted Abstract/Summary
The magnetic separation technology using sub-microsized ferromagnetic particle is indispensable in many areas of medical biosciences. For example, ferromagnetic particles (200-500 nm) are widely used for cell sorting in stem cell research with the use of cell surface-specific antigens. Nanosized ferromagnetic particles (10-20 nm) have been suggested as more suitable in drug delivery studies given their efficiency of tissue penetration, however, the magnetic separation method for them has not been established. One of the major reasons is that magnetic force acting on the object particles decreases drastically as a particle diameter becomes small. In this study, magnetic force acting on the targets was enhanced by the combination of superconducting magnet and the filter consisting of ferromagnetic particle. By doing so, we confirmed that Fe3O4 of 20 nm in diameter was trapped in the magnetic filter under an external magnetic field of 0.5 T. Fe3O4 encapsulated with phospholipid liposomes of 200 nm in diameter was also shown to be trapped as external magnetic field of 1.5 T, but not of 0.5 T. We also showed the result of particle trajectory calculation which emulated well the experimental data.
Subjects 3104 Condensed Matter Physics
2208 Electrical and Electronic Engineering
2504 Electronic, Optical and Magnetic Materials
Keyword Magnetic separation
Nanosized ferromagnetic particle
Superconducting magnet
Liposome
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: Institute for Molecular Bioscience - Publications
 
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