High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?

Thomas, Ranjeny, Turner, Malcolm and Cope, Andrew P. (2008) High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?. Arthritis Research and Therapy, 10 4: 1-9. doi:10.1186/ar2446

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Author Thomas, Ranjeny
Turner, Malcolm
Cope, Andrew P.
Title High avidity autoreactive T cells with a low signalling capacity through the T-cell receptor: central to rheumatoid arthritis pathogenesis?
Journal name Arthritis Research and Therapy   Check publisher's open access policy
ISSN 1478-6354
1478-6362
Publication date 2008-07-24
Year available 2008
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1186/ar2446
Open Access Status File (Publisher version)
Volume 10
Issue 4
Start page 1
End page 9
Total pages 9
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Abstract Self-reactive T cells with low signalling capacity through the T-cell receptor were recently observed in the SKG mouse model of rheumatoid arthritis (RA) and have been linked to a spontaneous mutation in the ZAP-70 signal transduction molecule. Here we hypothesize that similar mechanisms also drive RA, associated with an abnormal innate and adaptive immune response driven by nuclear factor-κB activation and tumour necrosis factor secretion. Similar to the essential role played by pathogens in SKG mice, we propose that HLA-associated immunity to chronic viral infection is a key factor in the immune dysregulation and joint inflammation that characterize RA.
Keyword Rheumatology
Rheumatology
RHEUMATOLOGY
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Diamantina Institute Publications
 
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