Correlation of plasma insulin concentration with laminitis score in a field study of equine cushing's disease and equine metabolic syndrome

Walsh, Donald M., McGowan, Catherine M., McGowan, Thomas, Lamb, Stephen V., Schanbacher, Barbara J. and Place, Ned J. (2009) Correlation of plasma insulin concentration with laminitis score in a field study of equine cushing's disease and equine metabolic syndrome. Journal of Equine Veterinary Science, 29 2: 87-94. doi:10.1016/j.jevs.2008.12.006


Author Walsh, Donald M.
McGowan, Catherine M.
McGowan, Thomas
Lamb, Stephen V.
Schanbacher, Barbara J.
Place, Ned J.
Title Correlation of plasma insulin concentration with laminitis score in a field study of equine cushing's disease and equine metabolic syndrome
Journal name Journal of Equine Veterinary Science   Check publisher's open access policy
ISSN 0737-0806
1542-7412
Publication date 2009-02-01
Sub-type Article (original research)
DOI 10.1016/j.jevs.2008.12.006
Open Access Status Not Open Access
Volume 29
Issue 2
Start page 87
End page 94
Total pages 8
Place of publication Maryland Heights, MO, United States
Publisher W.B. Saunders
Language eng
Formatted abstract
This study aimed to investigate endocrinologic test values and the response to treatment of two commonly encountered causes of endocrinopathic laminitis, equine Cushing's disease (ECD) and equine metabolic syndrome (EMS), in a veterinary practice setting. In particular, the study aimed to determine whether insulin concentration correlated to the severity of clinical laminitis in horses with EMS or ECD. Twenty-five horses were included in the study and assigned to one of three groups: ECD (n = 6), EMS (n = 10), and controls (n = 9). Blood samples were collected at an initial visit and then at regular intervals for the next 12 months. Plasma concentrations of adrenocorticotropin (ACTH), cortisol, and insulin and serum concentrations of glucose and total thyroxine (T4) were obtained. Horses with ECD had significantly higher plasma ACTH concentrations than EMS horses or controls. Horses with EMS and ECD both had significantly higher plasma insulin concentrations than control horses, which was correlated with the Obel grade of laminitis (r = 0.63). After treatment, there was a trend for a reduction in plasma ACTH concentration in horses with ECD. A program of diet and exercise for horses with EMS resulted in reductions in both plasma insulin concentrations and bodyweight, which was variable, depending on the individual. There was a significant correlation between the change in plasma insulin concentration and Obel grade of laminitis (r = 0.69). This study has highlighted the importance of baseline plasma insulin concentration as a potential indicator of the susceptibility of horses to laminitis and the response to a program of diet and exercise.
Keyword Cushing's
Insulin
Laminitis
Metabolic syndrome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Agriculture and Food Sciences
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 26 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 27 Nov 2013, 13:48:56 EST by System User on behalf of School of Agriculture and Food Sciences