Autonomic and neural correlates of dysregulated arousal in severe traumatic brain injury

Rushby, Jacqueline A., Fisher, Alana C., McDonald, Skye, Murphy, Anne and Finnigan, Simon (2013) Autonomic and neural correlates of dysregulated arousal in severe traumatic brain injury. International Journal of Psychophysiology, 89 3: 460-465. doi:10.1016/j.ijpsycho.2013.05.009

Author Rushby, Jacqueline A.
Fisher, Alana C.
McDonald, Skye
Murphy, Anne
Finnigan, Simon
Title Autonomic and neural correlates of dysregulated arousal in severe traumatic brain injury
Journal name International Journal of Psychophysiology   Check publisher's open access policy
ISSN 0167-8760
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.ijpsycho.2013.05.009
Open Access Status Not yet assessed
Volume 89
Issue 3
Start page 460
End page 465
Total pages 6
Place of publication Amsterdam, TheNetherlands
Publisher Elsevier BV
Language eng
Subject 2800 Neuroscience
2737 Physiology (medical)
3206 Neuropsychology and Physiological Psychology
Abstract Severe traumatic brain injury (TBI) in adults is associated with abnormalities in arousal and emotional responsivity, which are observed physiologically, behaviourally and via self-report measures. While an accurate measure of physiological arousal is debated, Barry et al. (2005, 2007, 2008) have consistently shown an inverse relationship between skin conductance level (SCL), and mean alpha power (alpha) during an eyes-closed resting condition (EC), accompanied by an increase in SCL and corresponding decrease in alpha during eyes-open (EO). Thus, alpha may provide a novel index of autonomic arousal. This study aimed to elucidate the neural and autonomic correlates of arousal disturbances in TBI.Participants were 17 adults with TBI (13 males; mean age 46.50) and 22 matched controls (14 males; mean age 41.25). Mean alpha and SCL were recorded across two 2. minute conditions (EC and EO). Paralleling previous research (e.g., Barry et al., 2007), a significant decrease in alpha was found from EC to EO for the sample overall, but this was significantly reduced in TBI participants. Further, TBI participants showed diminished regional differences compared to controls. Lower SCLs across EC-EO were also found in TBI participants compared to controls. Contrasting expectations, an increase in SCL from EC to EO was not found. This study showed that examining simple alpha changes provides insight into TBI-related arousal disturbances. Importantly, our findings accord with the nature of TBI, which involves global and region-specific damage.
Keyword Arousal
EEG alpha power
Skin conductance level
Traumatic brain injury
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID APP1013796
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 26 Nov 2013, 23:05:04 EST by Roheen Gill on behalf of UQ Centre for Clinical Research