Daily sitting time and all-cause mortality: A meta-analysis

Chau, Josephine Y., Grunseit, Anne C., Chey, Tien, Stamatakis, Emmanuel, Brown, Wendy J., Matthews, Charles E. and van der Ploeg, Hidde P. (2013) Daily sitting time and all-cause mortality: A meta-analysis. PLoS One, 8 11: e80000.1-e80000.14. doi:10.1371/journal.pone.0080000

Author Chau, Josephine Y.
Grunseit, Anne C.
Chey, Tien
Stamatakis, Emmanuel
Brown, Wendy J.
Matthews, Charles E.
van der Ploeg, Hidde P.
Title Daily sitting time and all-cause mortality: A meta-analysis
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-11-13
Sub-type Article (original research)
DOI 10.1371/journal.pone.0080000
Open Access Status DOI
Volume 8
Issue 11
Start page e80000.1
End page e80000.14
Total pages 14
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Objective: To quantify the association between daily total sitting and all-cause mortality risk and to examine dose-response relationships with and without adjustment for moderate-to-vigorous physical activity.

Methods: Studies published from 1989 to January 2013 were identified via searches of multiple databases, reference lists of systematic reviews on sitting and health, and from authors’ personal literature databases. We included prospective cohort studies that had total daily sitting time as a quantitative exposure variable, all-cause mortality as the outcome and reported estimates of relative risk, or odds ratios or hazard ratios with 95% confidence intervals. Two authors independently extracted the data and summary estimates of associations were computed using random effects models.

Results: Six studies were included, involving data from 595,086 adults and 29,162 deaths over 3,565,569 person-years of follow-up. Study participants were mainly female, middle-aged or older adults from high-income countries; mean study quality score was 12/15 points. Associations between daily total sitting time and all-cause mortality were not linear. With physical activity adjustment, the spline model of best fit had dose-response HRs of 1.00 (95% CI: 0.98-1.03), 1.02 (95% CI: 0.99-1.05) and 1.05 (95% CI: 1.02-1.08) for every 1-hour increase in sitting time in intervals between 0-3, >3-7 and >7 h/day total sitting, respectively. This model estimated a 34% higher mortality risk for adults sitting 10 h/day, after taking physical activity into account. The overall weighted population attributable fraction for all-cause mortality for total daily sitting time was 5.9%, after adjusting for physical activity.

Conclusions: Higher amounts of daily total sitting time are associated with greater risk of all-cause mortality and moderate-to-vigorous physical activity appears to attenuate the hazardous association. These findings provide a starting point for identifying a threshold on which to base clinical and public health recommendations for overall sitting time, in addition to physical activity guidelines.

Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Human Movement and Nutrition Sciences Publications
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Citation counts: TR Web of Science Citation Count  Cited 140 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 25 Nov 2013, 01:19:35 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences