Post-transplant lymphoproliferative disorder: no relationship to recombinant human growth hormone use in Australian and New Zealand pediatric kidney transplant recipients

Longmore, Danielle K., Conwell, Louise S., Burke, John R., McDonald, Stephen P. and McTaggart, Steven J. (2013) Post-transplant lymphoproliferative disorder: no relationship to recombinant human growth hormone use in Australian and New Zealand pediatric kidney transplant recipients. Pediatric Transplantation, 17 8: 731-736. doi:10.1111/petr.12167


Author Longmore, Danielle K.
Conwell, Louise S.
Burke, John R.
McDonald, Stephen P.
McTaggart, Steven J.
Title Post-transplant lymphoproliferative disorder: no relationship to recombinant human growth hormone use in Australian and New Zealand pediatric kidney transplant recipients
Journal name Pediatric Transplantation   Check publisher's open access policy
ISSN 1397-3142
1399-3046
Publication date 2013-12-01
Sub-type Article (original research)
DOI 10.1111/petr.12167
Volume 17
Issue 8
Start page 731
End page 736
Total pages 6
Place of publication Malden, United States
Publisher Wiley-Blackwell
Language eng
Abstract PTLD is a potentially life-limiting complication of pediatric transplantation. Previous registry-based studies in renal transplantation have suggested a link between rhGH use and PTLD. In this study, demographic and transplant data on those aged <18 yr and transplanted between 1991 and 2008 were collected from the ANZDATA Registry. Associations between gender, age at time of transplant, recipient CMV and EBV status, use of monoclonal antibody therapy, and use of rhGH were studied as potential predictors of PTLD. Among 650 transplants, there were 20 cases (3.1%) of PTLD, with half presenting within two yr post-transplant. Eight patients exposed to rhGH at any time developed PTLD, and this association was not statistically significant (RR = 1.5[0.6-3.4], p = 0.36). On multivariate analysis, there were no significant predictors for PTLD. In this study, previously identified potential risk factors were not identified as significant predictors for the development of PTLD. Although limited sample size may affect our ability to infer safety, this large retrospective cohort study does not suggest an increased risk of PTLD in pediatric kidney transplant recipients who received rhGH treatment.
Keyword Pediatrics
Post-transplant lymphoproliferative disease
Renal transplantation
Australian and New Zealand Dialysis and Transplant Registry
Recombinant human growth hormone
Kidney transplantation
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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