Noninvasive methods for the assessment of photoageing

Wheller, Laura, Lin, Lynlee L., Chai, Eric, Sinnya, Sudipta, Soyer, H. Peter and Prow, Tarl W. (2013) Noninvasive methods for the assessment of photoageing. Australasian Journal of Dermatology, 54 4: 290-295. doi:10.1111/ajd.12030

Author Wheller, Laura
Lin, Lynlee L.
Chai, Eric
Sinnya, Sudipta
Soyer, H. Peter
Prow, Tarl W.
Title Noninvasive methods for the assessment of photoageing
Journal name Australasian Journal of Dermatology   Check publisher's open access policy
ISSN 0004-8380
Publication date 2013-11-01
Sub-type Article (original research)
DOI 10.1111/ajd.12030
Volume 54
Issue 4
Start page 290
End page 295
Total pages 6
Place of publication Richmond Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Although histopathological dermal elastosis is the current gold standard for the diagnosis of photoageing, noninvasive methods for quantifying the amount of photodamage to skin are clearly preferable. This study is the first to survey five noninvasive methods of assessing photoageing (clinical examination, spectrophotometry, skin surface topography, reflectance confocal microscopy and fluorescence lifetime imaging microscopy) in the same individual. Measurements for each noninvasive method were compared across nine individuals from three participant groups (‘younger’, ‘older’ and ‘photodamaged’) in UV-protected volar and UV-exposed dorsal forearm skin. Overall, participants in the younger group had the lowest measures of photodamage, while those in the photodamaged group had the highest, as indicated by each modality. The five noninvasive strategies surveyed in this study may demonstrate potential as a suitable methodology for the quantification of photoageing. The advantage of such noninvasive methods is that they allow for skin visualisation in vivo and repeated assessments of the same site. The main limitation of this study was its small sample size, which may have precluded many findings of statistical significance.
Keyword fluorescence lifetime imaging microscopy
reflectance confocal microscopy
skin surface topography
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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