Bacterial mechanosensitive channels: models for studying mechanosensory transduction

Martinac, Boris, Nomura, Takeshi, Chi, Gamma, Petrov, Evgeny, Rohde, Paul R., Battle, Andrew R., Foo, Alexander, Constantine, Maryrose, Rothnagel, Rosalba, Carne, Sonia, Deplazes, Evelyne, Cornell, Bruce, Cranfield, Charles G., Hankamer, Ben and Landsberg, Michael J. (2014) Bacterial mechanosensitive channels: models for studying mechanosensory transduction. Antioxidants and Redox Signaling, 20 6: 952-969. doi:10.1089/ars.2013.5471

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Author Martinac, Boris
Nomura, Takeshi
Chi, Gamma
Petrov, Evgeny
Rohde, Paul R.
Battle, Andrew R.
Foo, Alexander
Constantine, Maryrose
Rothnagel, Rosalba
Carne, Sonia
Deplazes, Evelyne
Cornell, Bruce
Cranfield, Charles G.
Hankamer, Ben
Landsberg, Michael J.
Title Bacterial mechanosensitive channels: models for studying mechanosensory transduction
Journal name Antioxidants and Redox Signaling   Check publisher's open access policy
ISSN 1523-0864
1557-7716
Publication date 2014-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1089/ars.2013.5471
Open Access Status File (Author Post-print)
Volume 20
Issue 6
Start page 952
End page 969
Total pages 18
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert Publishers
Language eng
Formatted abstract
Significance: Sensations of touch and hearing are manifestations of mechanical contact and air pressure acting on touch receptors and hair cells of the inner ear, respectively. In bacteria, osmotic pressure exerts a significant mechanical force on their cellular membrane. Bacteria have evolved mechanosensitive (MS) channels to cope with excessive turgor pressure resulting from a hypo-osmotic shock. MS channel opening allows the expulsion of osmolytes and water, thereby restoring normal cellular turgor and preventing cell lysis.

Recent Advances: As biological force-sensing systems, MS channels have been identified as the best examples of membrane proteins coupling molecular dynamics to cellular mechanics. The bacterial MS channel of large conductance (MscL) and MS channel of small conductance (MscS) have been subjected to extensive biophysical, biochemical, genetic, and structural analyses. These studies have established MscL and MscS as model systems for mechanosensory transduction.

Critical Issues: In recent years, MS ion channels in mammalian cells have moved into focus of mechanotransduction research, accompanied by an increased awareness of the role they may play in the pathophysiology of diseases, including cardiac hypertrophy, muscular dystrophy, or Xerocytosis.

Future Directions: A recent exciting development includes the molecular identification of Piezo proteins, which function as nonselective cation channels in mechanosensory transduction associated with senses of touch and pain. Since research on Piezo channels is very young, applying lessons learned from studies of bacterial MS channels to establishing the mechanism by which the Piezo channels are mechanically activated remains one of the future challenges toward a better understanding of the role that MS channels play in mechanobiology.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes This is a copy of an article published in the Antioxidants and Redox Signaling ©2013 copyright Mary Ann Liebert, Inc.; Antioxidants and Redox Signaling is available online at: http://online.liebertpub.com. Authors may also deposit this version on his/her funder's or funder's designated re

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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Created: Sat, 23 Nov 2013, 00:05:35 EST by Susan Allen on behalf of Chemistry, Department of