Antibiotics in the clinical pipeline in 2013

Butler, Mark S., Blaskovich, Mark A. and Cooper, Matthew A. (2013) Antibiotics in the clinical pipeline in 2013. Journal of Antibiotics, 66 10: 571-591. doi:10.1038/ja.2013.86

Author Butler, Mark S.
Blaskovich, Mark A.
Cooper, Matthew A.
Title Antibiotics in the clinical pipeline in 2013
Journal name Journal of Antibiotics   Check publisher's open access policy
ISSN 0021-8820
Publication date 2013-09-04
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/ja.2013.86
Open Access Status Not Open Access
Volume 66
Issue 10
Start page 571
End page 591
Total pages 22
Place of publication London, United Kingdom
Publisher Nature Publishing
Language eng
Subject 3004 Pharmacology
3002 Drug Discovery
Abstract The continued emergence of multi-drug-resistant bacteria is a major public health concern. The identification and development of new antibiotics, especially those with new modes of action, is imperative to help treat these infections. This review lists the 22 new antibiotics launched since 2000 and details the two first-in-class antibiotics, fidaxomicin (1) and bedaquiline (2), launched in 2011 and 2012, respectively. The development status, mode of action, spectra of activity, historical discovery and origin of the drug pharmacophore (natural product, natural product derived, synthetic or protein/mammalian peptide) of the 49 compounds and 6 β-lactamase/β-lactam combinations in active clinical development are discussed, as well as compounds that have been discontinued from clinical development since 2011. New antibacterial pharmacophore templates are also reviewed and analyzed.
Keyword Antibiotic
Antimicrobial resistance
Clinical trials
Drug development
Drug discovery
Natural product
Q-Index Code CX
Q-Index Status Confirmed Code
Grant ID 094977
Institutional Status UQ
Additional Notes Published online: 4 September 2013.

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Non HERDC
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Created: Thu, 21 Nov 2013, 21:15:06 EST by Susan Allen on behalf of Institute for Molecular Bioscience