Cyclic peptide marine metabolites and CuII

Comba, Peter, Dovalil, Nina, Gahan, Lawrence R., Hanson, Graeme R. and Westphal, Michael (2014) Cyclic peptide marine metabolites and CuII. Dalton Transactions, 43 5: 1935-1956. doi:10.1039/c3dt52664j

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Author Comba, Peter
Dovalil, Nina
Gahan, Lawrence R.
Hanson, Graeme R.
Westphal, Michael
Title Cyclic peptide marine metabolites and CuII
Formatted title
Cyclic peptide marine metabolites and CuII
Journal name Dalton Transactions   Check publisher's open access policy
ISSN 1477-9226
Publication date 2014-02-04
Year available 2013
Sub-type Article (original research)
DOI 10.1039/c3dt52664j
Open Access Status File (Publisher version)
Volume 43
Issue 5
Start page 1935
End page 1956
Total pages 22
Place of publication Cambridge, United Kingdom
Publisher RSC Publications
Language eng
Formatted abstract
Cyclic pseudo-peptides derived from marine metabolites of the genus Lissoclinum bistratum and Lissoclinum patella have attracted scientific interest in the last two decades. Their structural properties and solution dynamics have been analyzed in detail, elaborate synthetic procedures for the natural products and synthetic derivatives developed, the biosynthetic pathways studied and it now is possible to produce them biosynthetically. Initially, these macrocyclic ligands were studied due to their medicinal and pharmaceutical potential – some of the isolated cyclic pseudo-peptides show high cytotoxic and antiviral activity. A major focus in the last decade has been on their CuII coordination chemistry, as a number of studies have indicated that dinuclear CuII complexes of cyclic peptides may be involved in the ascidians’ metabolism, and this is the focus of the present review.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 30 October 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Chemistry and Molecular Biosciences
Centre for Advanced Imaging Publications
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Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
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Created: Wed, 20 Nov 2013, 22:38:11 EST by Anna Cotroneo on behalf of School of Chemistry & Molecular Biosciences