Comparison of block and event-related experimental designs in diffusion-weighted functional MRI

Williams, Rebecca J., McMahon, Katie L., Hocking, Julia and Reutens, David C. (2013) Comparison of block and event-related experimental designs in diffusion-weighted functional MRI. Journal of Magnetic Resonance Imaging, 40 2: 1-9. doi:10.1002/jmri.24353

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Author Williams, Rebecca J.
McMahon, Katie L.
Hocking, Julia
Reutens, David C.
Title Comparison of block and event-related experimental designs in diffusion-weighted functional MRI
Journal name Journal of Magnetic Resonance Imaging   Check publisher's open access policy
ISSN 1053-1807
1522-2586
Publication date 2013-10-29
Year available 2013
Sub-type Article (original research)
DOI 10.1002/jmri.24353
Open Access Status Not yet assessed
Volume 40
Issue 2
Start page 1
End page 9
Total pages 9
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Abstract Purpose: To compare diffusion-weighted functional magnetic resonance imaging (DfMRI), a novel alternative to the blood oxygenation level-dependent (BOLD) contrast, in a functional MRI experiment.
Formatted abstract
Purpose To compare diffusion-weighted functional magnetic resonance imaging (DfMRI), a novel alternative to the blood oxygenation level-dependent (BOLD) contrast, in a functional MRI experiment.

Materials and Methods Nine participants viewed contrast reversing (7.5 Hz) black-and-white checkerboard stimuli using block and event-related paradigms. DfMRI (b = 1800 mm/s2) and BOLD sequences were acquired. Four parameters describing the observed signal were assessed: percent signal change, spatial extent of the activation, the Euclidean distance between peak voxel locations, and the time-to-peak of the best fitting impulse response for different paradigms and sequences.

Results The BOLD conditions showed a higher percent signal change relative to DfMRI; however, event-related DfMRI showed the strongest group activation (t = 21.23, P < 0.0005). Activation was more diffuse and spatially closer to the BOLD response for DfMRI when the block design was used. DfMRIevent showed the shortest TTP (4.4 ± 0.88 sec).

Conclusion The hemodynamic contribution to DfMRI may increase with the use of block designs.
Keyword fMRI
Diffusion
DfMRI
Visual cortex
BOLD
Experimental design
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 29 OCT 2013

 
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Created: Wed, 20 Nov 2013, 00:02:32 EST by Anna Cotroneo on behalf of Centre for Advanced Imaging