Sulforaphane: translational research from laboratory bench to clinic

Houghton, Christine A., Fassett, Robert G. and Coombes, Jeff S. (2013) Sulforaphane: translational research from laboratory bench to clinic. Nutrition Reviews, 71 11: 709-726. doi:10.1111/nure.12060


Author Houghton, Christine A.
Fassett, Robert G.
Coombes, Jeff S.
Title Sulforaphane: translational research from laboratory bench to clinic
Journal name Nutrition Reviews   Check publisher's open access policy
ISSN 0029-6643
1753-4887
Publication date 2013-11-01
Sub-type Article (original research)
DOI 10.1111/nure.12060
Volume 71
Issue 11
Start page 709
End page 726
Total pages 18
Place of publication Washington, DC, United States
Publisher International Life Sciences Institute
Language eng
Formatted abstract
Cruciferous vegetables are widely acknowledged to provide chemopreventive benefits in humans, but they are not generally consumed at levels that effect significant change in biomarkers of health. Because consumers have embraced the notion that dietary supplements may prevent disease, this review considers whether an appropriately validated sulforaphane-yielding broccoli sprout supplement may deliver clinical benefit. The crucifer-derived bioactive phytochemical sulforaphane is a significant inducer of nuclear factor erythroid 2-related factor 2 (Nrf2), the transcription factor that activates the cell's endogenous defenses via a battery of cytoprotective genes. For a broccoli sprout supplement to demonstrate bioactivity in vivo, it must retain both the sulforaphane-yielding precursor compound, glucoraphanin, and the activity of glucoraphanin's intrinsic myrosinase enzyme. Many broccoli sprout supplements are myrosinase inactive, but current labeling does not reflect this. For the benefit of clinicians and consumers, this review summarizes the findings of in vitro studies and clinical trials, interpreting them in the context of clinical relevance. Standardization of sulforaphane nomenclature and assay protocols will be necessary to remove inconsistency and ambiguity in the labeling of currently available broccoli sprout products.
Keyword Bioactivity
Bioavailability
Broccoli seed extract
Broccoli sprout
Glucoraphanin
Myrosinase-active
Sulforaphane
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Human Movement and Nutrition Sciences Publications
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 48 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 52 times in Scopus Article | Citations
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Created: Sun, 17 Nov 2013, 22:38:18 EST by Deborah Noon on behalf of School of Human Movement and Nutrition Sciences