Developmental programming: variations in early growth and adult disease

Gallo, Linda A., Tran, Melanie, Moritz, Karen M. and Wlodek, Mary E. (2013) Developmental programming: variations in early growth and adult disease. Clinical and Experimental Pharmacology and Physiology, 40 11: 795-802. doi:10.1111/1440-1681.12092


Author Gallo, Linda A.
Tran, Melanie
Moritz, Karen M.
Wlodek, Mary E.
Title Developmental programming: variations in early growth and adult disease
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 0305-1870
1440-1681
Publication date 2013-11-01
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1111/1440-1681.12092
Open Access Status
Volume 40
Issue 11
Start page 795
End page 802
Total pages 8
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Language eng
Abstract Suboptimal conditions in utero are associated with the development of adult-onset diseases in offspring. Uteroplacental insufficiency in rats is a well-established animal model used to mimic and study the effects of developmental insults relevant to countries of abundant nutrient supply. However, wide-ranging outcomes for the offspring are apparent between the different investigators that use this model and also between cohorts generated in our laboratory. We aimed to explore the reasons for variability in rat models of uteroplacental insufficiency between different investigators and also between our own animal cohorts. We suggest differences in growth and disease development reflect uniqueness in susceptibility and highlight the complexity of interactions between genetic potential and environmental exposures. The impact of adverse exposures in utero has been described as having far-reaching effects that extend well beyond the first, directly exposed generation. However, the resulting phenotypes are not consistent between generations. This suggests that programmed effects are established de novo in each generation and challenges the prediction of disease. Characterization of growth and disease in the numerous rat models has led to our understanding of the impact of early life experiences on adult health. In order to drive the development of preventative and/or treatment strategies, future studies should focus on identifying the initial cause(s) of uteroplacental insufficiency, including genetic origins and the influence of poor diets.
Keyword Animal models
Early life exposures
Transgenerational effects
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Mater Research Institute-UQ (MRI-UQ)
Official 2014 Collection
School of Biomedical Sciences Publications
 
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