Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis

Leishman, Shaneen J., Seymour, Gregory J. and Ford, Pauline J. (2013) Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis. Disease Markers, 35 5: 543-549. doi:10.1155/2013/948569

Author Leishman, Shaneen J.
Seymour, Gregory J.
Ford, Pauline J.
Title Local and Systemic Inflammatory Responses to Experimentally Induced Gingivitis
Journal name Disease Markers   Check publisher's open access policy
ISSN 0278-0240
Publication date 2013-01-01
Year available 2013
Sub-type Article (original research)
DOI 10.1155/2013/948569
Open Access Status DOI
Volume 35
Issue 5
Start page 543
End page 549
Total pages 7
Place of publication New York, NY United States
Publisher Hindawi Publishing Corporation
Language eng
Formatted abstract
This study profiled the local and systemic inflammatory responses to experimentally induced gingivitis. Eight females participated in a 21-day experimental gingivitis model followed by a 14-day resolution phase. Bleeding on probing and plaque index scores were assessed before, during, and after resolution of gingival inflammation, and samples of saliva, GCF, and plasma were collected. Samples were assessed for biomarkers of inflammation using the BioPlex platform and ELISA. There were no significant changes in GCF levels of cytokines during the experimental phase; however, individual variability in cytokine profiles was noted. During resolution, mean GCF levels of IL-2, IL-6, and TNF-alpha decreased and were significantly lower than baseline levels (P = 0.003, P - 0.025, and P - 0.007, resp.). Furthermore, changes in GCF levels of IL-2, IL-6, and TNF-alpha during resolution correlated with changes in plaque index scores (P = 0.88, P = 0.004; P = 0.72, P = 0.042; P = 0.79, P = 0.019, resp.). Plasma levels of sICAM-1 increased significantly during the experimental phase (P = 0.002) and remained elevated and significantly higher than baseline levels during resolution (P < 0.001). These results support the concept that gingivitis adds to the systemic inflammatory burden of an individual.
Keyword Intercellular Adhesion Molecule 1
C reactive protein
Necrosis factor alpha
Crevicular Fluid
Periodontal Infections
Cardiovascular disease (CVD)
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Dentistry Publications
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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