Direction selectivity is computed by active dendritic integration in retinal ganglion cells

Sivyer, Benjamin and Williams, Stephen R. (2013) Direction selectivity is computed by active dendritic integration in retinal ganglion cells. Nature Neuroscience, 16 12: 1848-1857. doi:10.1038/nn.3565


Author Sivyer, Benjamin
Williams, Stephen R.
Title Direction selectivity is computed by active dendritic integration in retinal ganglion cells
Journal name Nature Neuroscience   Check publisher's open access policy
ISSN 1097-6256
1546-1726
Publication date 2013-12-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/nn.3565
Open Access Status
Volume 16
Issue 12
Start page 1848
End page 1857
Total pages 10
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Formatted abstract
Active dendritic integration is thought to enrich the computational power of central neurons. However, a direct role of active dendritic processing in the execution of defined neuronal computations in intact neural networks has not been established. Here we used multi-site electrophysiological recording techniques to demonstrate that active dendritic integration underlies the computation of direction selectivity in rabbit retinal ganglion cells. Direction-selective retinal ganglion cells fire action potentials in response to visual image movement in a preferred direction. Dendritic recordings revealed that preferred-direction moving-light stimuli led to dendritic spike generation in terminal dendrites, which were further integrated and amplified as they spread through the dendritic arbor to the axon to drive action potential output. In contrast, when light bars moved in a null direction, synaptic inhibition vetoed neuronal output by directly inhibiting terminal dendritic spike initiation. Active dendritic integration therefore underlies a physiologically engaged circuit-based computation in the retina.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online 27 October 2013

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 31 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 31 times in Scopus Article | Citations
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Created: Wed, 13 Nov 2013, 23:52:27 EST by Debra McMurtrie on behalf of Queensland Brain Institute