Linkage study of schizophrenia to markers within Xp11 near the MAOB gene

Dann, J, DeLisi, LE, Devoto, M, Laval, S, Nancarrow, DJ, Shields, G, Smith, A, Loftus, J, Peterson, P, Vita, A, Comazzi, M, Invernizzi, G, Levinson, DF, Wildenauer, D, Mowry, BJ, Collier, D, Powell, J, Crowe, RR, Andreasen, NC, Silverman, JM, Mohs, RC, Murray, RM, Walters, MK, Lennon, DP, Hayward, NK, Albus, M, Lerer, B, Maier, W and Crow, TJ (1997) Linkage study of schizophrenia to markers within Xp11 near the MAOB gene. Psychiatry Research, 70 3: 131-143. doi:10.1016/S0165-1781(97)03138-7


Author Dann, J
DeLisi, LE
Devoto, M
Laval, S
Nancarrow, DJ
Shields, G
Smith, A
Loftus, J
Peterson, P
Vita, A
Comazzi, M
Invernizzi, G
Levinson, DF
Wildenauer, D
Mowry, BJ
Collier, D
Powell, J
Crowe, RR
Andreasen, NC
Silverman, JM
Mohs, RC
Murray, RM
Walters, MK
Lennon, DP
Hayward, NK
Albus, M
Lerer, B
Maier, W
Crow, TJ
Title Linkage study of schizophrenia to markers within Xp11 near the MAOB gene
Journal name Psychiatry Research   Check publisher's open access policy
ISSN 0165-1781
Publication date 1997-05-01
Sub-type Article (original research)
DOI 10.1016/S0165-1781(97)03138-7
Open Access Status
Volume 70
Issue 3
Start page 131
End page 143
Total pages 13
Language eng
Subject 2738 Psychiatry and Mental health
2803 Biological Psychiatry
Abstract A sex chromosome locus for psychosis has been considered on the basis of some sex differences in genetic risk and expression of illness, and an association with X-chromosome anomalies. Previous molecular genetic studies produced weak evidence for linkage of schizophrenia to the proximal short arm of the X-chromosome, while some other regions were not ruled out. Here we report an attempt to expand the Xp findings in: (i) a multicenter collaboration focusing on 92 families with a maternal pattern of inheritance (Study I.); and (ii) an independent sample of 34 families unselected for parental mode of transmission (Study II.). In the multicenter study, a parametric analysis resulted in positive lod scores (highest of 1.97 for dominant and 1.19 for recessive inheritance at a theta of 0.20) for locus DXS7, with scores below 0.50 for other markers in this region (MAOB, DXS228, and ARAF1). Significant allele sharing among affected sibling pairs was present at DXS7. In the second study, positive lod scores were observed at MAOB (highest of 2.16 at a theta of 0.05 for dominant and 1.64 at a theta of 0.00 for recessive models) and ALAS2 (the highest of 1.36 at a theta of 0.05 for a recessive model), with significant allele sharing (P=0.003 and 0.01, respectively) at these two loci. These five markers are mapped within a small region of Xp11. Thus, although substantial regions of the X-chromosome have been investigated without evidence for linkage being found, a locus predisposing to schizophrenia in the proximal short arm of the X-chromosome is not excluded.
Keyword schizoaffective disorder
sib-pair analysis
Dxs7
Dxs228
Araf1
Alas2
Bipolar Affective-Disorder
Monoamine-Oxidase Activity
Pseudoautosomal Locus
A Gene
Sibling Pairs
No Evidence
Association
Replication
Chromosome
Sex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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