The molecular genetics of schizophrenia: an update

Mowry, BJ, Nancarrow, DJ and Levinson, DF (1997) The molecular genetics of schizophrenia: an update. Australian and New Zealand Journal of Psychiatry, 31 5: 704-713. doi:10.3109/00048679709062684


Author Mowry, BJ
Nancarrow, DJ
Levinson, DF
Title The molecular genetics of schizophrenia: an update
Journal name Australian and New Zealand Journal of Psychiatry   Check publisher's open access policy
ISSN 0004-8674
Publication date 1997-10-01
Sub-type Article (original research)
DOI 10.3109/00048679709062684
Open Access Status
Volume 31
Issue 5
Start page 704
End page 713
Total pages 10
Publisher SAGE Publications Ltd
Language eng
Subject 2738 Psychiatry and Mental health
Abstract Objective: This paper aims to summarise the latest molecular genetic findings in schizophrenia, while providing background information on a number of relevant methodological issues. Method: Accumulative genetic data indicate that schizophrenia is a genetically complex disease with an unclear mode of transmission. The development and rapid progression of molecular genetics have provided a wide variety of methods to search for genes predisposing to human disease. The genetic basis for a number of the simpler diseases has been identified and characterised using these methods. More recently, progress has been made in identifying genes predisposing to the genetically more complex diseases such as diabetes mellitus, multiple sclerosis, bipolar disorder and schizophrenia. Results: The latest findings on chromosomes 3, 6, 8, 13, 18 and 22 and on the X chromosome are reviewed. Conclusions: There is now suggestive support for three susceptibility loci (6p24-22, 8p22-21 and 22q12-q13.1) for schizophrenia, and it is likely that other regions will emerge from studies now in progress. Finding and then characterising genes within these loci will require long-term commitment and systematic efforts in clinical, laboratory and analytical fields.
Keyword complex genetic diseases
linkage
molecular genetics
schizophrenia
Chromosome 5Q11-Q13 Markers
Dopamine-Receptor Gene
Cardio-Facial Syndrome
Pair Linkage Analysis
Potential Linkage
Susceptibility Gene
Schizoaffective Disorder
Psychiatric-Disorders
Future-Directions
Controlled Family
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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