In vitro evaluation of aortic insufficiency with a rotary left ventricular assist device

Gregory, Shaun D., Stevens, Michael C., Wu, Eric, Fraser, John F. and Timms, Daniel (2013) In vitro evaluation of aortic insufficiency with a rotary left ventricular assist device. Artificial Organs, 37 9: 802-809. doi:10.1111/aor.12143

Author Gregory, Shaun D.
Stevens, Michael C.
Wu, Eric
Fraser, John F.
Timms, Daniel
Title In vitro evaluation of aortic insufficiency with a rotary left ventricular assist device
Journal name Artificial Organs   Check publisher's open access policy
ISSN 0160-564X
Publication date 2013-09-01
Year available 2013
Sub-type Article (original research)
DOI 10.1111/aor.12143
Open Access Status
Volume 37
Issue 9
Start page 802
End page 809
Total pages 8
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell
Language eng
Abstract Aortic insufficiency (AI) is usually repaired prior to rotary blood pump (RBP) implantation but can develop during support due, in part, to the sustained RBP-induced high pressure gradient across the aortic valve. Repair of the aortic valve before or during RBP support predisposes these critically ill patients to even higher risks. This study used an in vitro mock circulation loop to identify the severity of AI and/or left heart failure (LHF) that might benefit from valve repair while investigating RBP operating strategies to reduce the hemodynamic influence of AI. Reproduction of AI with RBP-supported LHF reduced device efficiency, particularly in the more severe cases of AI and LHF. The requirement for repair or closure of the aortic valve was demonstrated in all conditions other than those with only mild AI. When a sinusoidal RBP speed pulse was induced, small changes in systemic flow rate and regurgitant volume were observed with all degrees of AI. Variation of the pulse phase delay only resulted in minor changes to systemic flow rate, with a maximum difference of 0.17 L/min. Although the clinical implications of these small changes may be insignificant, changes in systemic flow rate and transvalvular pressure were shown when the sinusoidal RBP speed pulse was applied with no AI. In these cases, transvalvular pressure was reduced by up to 8% through sinusoidal copulsation of the RBP, which may prevent or delay the onset of AI. This in vitro study suggests that surgical intervention is required with moderate or worse AI and that RBP operating strategies should be further explored to delay the onset and reduce the harmful effects of AI.
Keyword Aortic insufficiency
Ventricular assist device
Rotary blood pump
Mock circulation loop
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID NR2010-118
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Medicine Publications
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