Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma

Le Page, M. E. L., Goodridge, J. P., Zhang, G., Holt, P. G., Sly, P. and Witt, C. S. (2013) Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma. Tissue Antigens, 82 4: 276-279. doi:10.1111/tan.12185


Author Le Page, M. E. L.
Goodridge, J. P.
Zhang, G.
Holt, P. G.
Sly, P.
Witt, C. S.
Title Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma
Formatted title
Genetic polymorphism of KIR2DL4 (CD158d), a putative NK cell receptor for HLA-G, does not influence susceptibility to asthma
Journal name Tissue Antigens   Check publisher's open access policy
ISSN 0001-2815
1399-0039
Publication date 2013-10-01
Sub-type Article (original research)
DOI 10.1111/tan.12185
Volume 82
Issue 4
Start page 276
End page 279
Total pages 4
Place of publication Malden, MA, United States
Publisher Wiley-Blackwell
Language eng
Abstract Human leukocyte antigen (HLA)-G is upregulated on the bronchial epithelium of asthma patients and genetic polymorphism affecting expression of HLA-G has been reported to influence susceptibility to asthma. As the NK cell receptor KIR2DL4 has been reported to induce interferon gamma (IFNγ) secretion when ligated with HLA-G, we postulated that the 9A/10A genetic polymorphism of KIR2DL4 which influences receptor structure may influence susceptibility to asthma. KIR2DL4 genotypes were determined in two cohorts of children (n=219 and n=1356) in whom total serum IgE, allergen-specific IgE, atopy, bronchial reactivity and asthma symptoms had been studied between birth and 14years. No reproducible associations with KIR2DL4 genotype were identified, leading us to conclude that the KIR2DL4 9A/10A polymorphism has no influence on susceptibility to asthma.
Keyword Asthma
Atopy
CD158d
KIR2DL4
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Queensland Children's Medical Research Institute Publications
 
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