A genome-wide analysis of annexins from parasitic organisms and their vectors

Cantacessi, Cinzia, Seddon, Jennifer M., Miller, Terrence L., Leow, Chiuan Yee, Thomas, Laetitia, Mason, Lyndel, Willis, Charlene, Walker, Giselle, Loukas, Alex, Gasser, Robin B., Jones, Malcolm K. and Hofmann, Andreas (2013) A genome-wide analysis of annexins from parasitic organisms and their vectors. Scientific Reports, 3 2893.1-2893.8. doi:10.1038/srep02893


Author Cantacessi, Cinzia
Seddon, Jennifer M.
Miller, Terrence L.
Leow, Chiuan Yee
Thomas, Laetitia
Mason, Lyndel
Willis, Charlene
Walker, Giselle
Loukas, Alex
Gasser, Robin B.
Jones, Malcolm K.
Hofmann, Andreas
Title A genome-wide analysis of annexins from parasitic organisms and their vectors
Journal name Scientific Reports   Check publisher's open access policy
ISSN 2045-2322
Publication date 2013-10-01
Sub-type Article (original research)
DOI 10.1038/srep02893
Open Access Status DOI
Volume 3
Start page 2893.1
End page 2893.8
Total pages 8
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
In this study, we conduct an in-depth analysis of annexin proteins from a diverse range of invertebrate taxa, including the major groups that contain the parasites and vector organisms that are harmful to humans and domestic animals. Using structure-based amino acid sequence alignments and phylogenetic analyses, we present a classification for this protein group and assign names to sequences with ambiguous annotations in public databases. Our analyses reveal six distinct annexin clades, and the mapping of genes encoding annexins to the genome of the human blood fluke Schistosoma mansoni supports the hypothesis of gene duplication as a major evolutionary event in annexin genesis. This study illuminates annexin diversity from a novel perspective using contemporary phylogenetic hypotheses of eukaryote evolution, and will aid the consolidation of annexin protein identities in public databases and provide a foundation for future functional analysis and characterisation of these proteins in parasites of socioeconomic importance.
Keyword Schistosoma mansoni
Plant Annexins
Platyhelminthes
Phylogeny
Protein
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article number 2893

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Veterinary Science Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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