Genome-wide association analysis identifies 13 new risk loci for schizophrenia

Ripke, Stephan, O'Dushlaine, Colm, Chambert, Kimberly, Moran, Jennifer L., Kaehler, Anna K., Akterin, Susanne, Bergen, Sarah E., Collins, Ann L., Crowley, James J., Fromer, Menachem, Kim, Yunjung, Lee, Sang Hong, Magnusson, Patrik K. E., Sanchez, Nick, Stahl, Eli A., Williams, Stephanie, Wray, Naomi R., Xia, Kai, Bettella, Francesco, Borglum, Anders D., Bulik-Sullivan, Brendan K., Cormican, Paul, Craddock, Nick, de Leeuw, Christiaan, Durmishi, Naser, Gill, Michael, Golimbet, Vera, Hamshere, Marian L., Holmans, Peter, Hougaard, David M., Kendler, Kenneth S., Lin, Kuang, Morris, Derek W., Mors, Ole, Mortensen, Preben B., Neale, Benjamin M., O'Neill, Francis A., Owen, Michael J., Milovancevic, Milica Pejovic, Posthuma, Danielle, Powell, John, Richards, Alexander L., Riley, Brien P., Ruderfer, Douglas, Rujescu, Dan, Sigurdsson, Engilbert, Silagadze, Teimuraz, Smit, August B., Stefansson, Hreinn, Steinberg, Stacy, Suvisaari, Jaana, Tosato, Sarah, Verhage, Matthijs, Walters, James T., Multicenter Genetic Studies of Schizophrenia Consortium, Psychosis Endophenotypes International Consortium, Wellcome Trust Case Control Consortium 2,, Bramon, Elvira, Corvin, Aiden P., O'Donovan, Michael C., Stefansson, Kari, Scolnick, Edward, Purcell, Shaun, McCarroll, Steven A., Sklar, Pamela, Hultman, Christina M., Sullivan, Patrick F., Mowry, Bryan J., Nertney, Deborah A. and Brown, Matthew A (2013) Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nature Genetics, 45 10: 1150-U282. doi:10.1038/ng.2742

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Author Ripke, Stephan
O'Dushlaine, Colm
Chambert, Kimberly
Moran, Jennifer L.
Kaehler, Anna K.
Akterin, Susanne
Bergen, Sarah E.
Collins, Ann L.
Crowley, James J.
Fromer, Menachem
Kim, Yunjung
Lee, Sang Hong
Magnusson, Patrik K. E.
Sanchez, Nick
Stahl, Eli A.
Williams, Stephanie
Wray, Naomi R.
Xia, Kai
Bettella, Francesco
Borglum, Anders D.
Bulik-Sullivan, Brendan K.
Cormican, Paul
Craddock, Nick
de Leeuw, Christiaan
Durmishi, Naser
Gill, Michael
Golimbet, Vera
Hamshere, Marian L.
Holmans, Peter
Hougaard, David M.
Kendler, Kenneth S.
Lin, Kuang
Morris, Derek W.
Mors, Ole
Mortensen, Preben B.
Neale, Benjamin M.
O'Neill, Francis A.
Owen, Michael J.
Milovancevic, Milica Pejovic
Posthuma, Danielle
Powell, John
Richards, Alexander L.
Riley, Brien P.
Ruderfer, Douglas
Rujescu, Dan
Sigurdsson, Engilbert
Silagadze, Teimuraz
Smit, August B.
Stefansson, Hreinn
Steinberg, Stacy
Suvisaari, Jaana
Tosato, Sarah
Verhage, Matthijs
Walters, James T.
Multicenter Genetic Studies of Schizophrenia Consortium
Psychosis Endophenotypes International Consortium
Wellcome Trust Case Control Consortium 2,
Bramon, Elvira
Corvin, Aiden P.
O'Donovan, Michael C.
Stefansson, Kari
Scolnick, Edward
Purcell, Shaun
McCarroll, Steven A.
Sklar, Pamela
Hultman, Christina M.
Sullivan, Patrick F.
Mowry, Bryan J.
Nertney, Deborah A.
Brown, Matthew A
Title Genome-wide association analysis identifies 13 new risk loci for schizophrenia
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ng.2742
Open Access Status File (Author Post-print)
Volume 45
Issue 10
Start page 1150
End page U282
Total pages 12
Place of publication New York, NY United States
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophrenia beginning with a Swedish national sample (5,001 cases and 6,243 controls) followed by meta-Analysis with previous schizophrenia GWAS (8,832 cases and 12,067 controls) and finally by replication of SNPs in 168 genomic regions in independent samples (7,413 cases, 19,762 controls and 581 parent-offspring trios). We identified 22 loci associated at genome-wide significance; 13 of these are new, and 1 was previously implicated in bipolar disorder. Examination of candidate genes at these loci suggests the involvement of neuronal calcium signaling. We estimate that 8,300 independent, mostly common SNPs (95% credible interval of 6,300-10,200 SNPs) contribute to risk for schizophrenia and that these collectively account for at least 32% of the variance in liability. Common genetic variation has an important role in the etiology of schizophrenia, and larger studies will allow more detailed understanding of this disorder.
Keyword Dependent Calcium-Channels
Bipolar Disorder
Common Variants
Spatial Memory
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID R01 MH077139
NWO 645-000-003
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Brain Institute Publications
Official 2014 Collection
UQ Diamantina Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 655 times in Thomson Reuters Web of Science Article | Citations
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