Effect of supracervical apposition and spontaneous labour on apoptosis and matrix metalloproteinases in human fetal membranes

Chai, Mahalia, Walker, Susan P., Riley, Clyde, Rice, Gregory E., Permezel, Michael and Lappas, Martha (2013) Effect of supracervical apposition and spontaneous labour on apoptosis and matrix metalloproteinases in human fetal membranes. BioMed Research International, 2013 316146.1-316146.10. doi:10.1155/2013/316146

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Author Chai, Mahalia
Walker, Susan P.
Riley, Clyde
Rice, Gregory E.
Permezel, Michael
Lappas, Martha
Title Effect of supracervical apposition and spontaneous labour on apoptosis and matrix metalloproteinases in human fetal membranes
Journal name BioMed Research International   Check publisher's open access policy
ISSN 2314-6133
2314-6141
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.1155/2013/316146
Open Access Status DOI
Volume 2013
Start page 316146.1
End page 316146.10
Total pages 10
Place of publication New York, NY, United States
Publisher Hindawi Publishing
Language eng
Formatted abstract
Background: Apoptosis and matrix metalloproteinase (MMP-9) are capable of hydrolysing components of the extracellular matrix and weakening the fetal membranes which leads to eventual rupture, a key process of human parturition. The aim of this study was to determine the effect of supracervical apposition and spontaneous labour on apoptosis and MMP-9 in human fetal membranes at term.

Methods: Fetal membranes were obtained from term non-labouring supracervical site (SCS) and compared to (i) a paired distal site (DS) or (ii) site of rupture (SOR) after spontaneous labour onset.

Results: The expression of the proapoptotic markers Bax, Smac, Fas, FasL, caspase-3, and PARP, was significantly higher in the non-labouring SCS chorion compared to paired DS. Bax, Smac, FasL, caspase-3, and PARP staining was higher in the non-labouring SCS fetal membranes than that in the post-labour SOR. MMP-9 expression and activity were higher in the post-labour SOR fetal membranes compared to non-labouring SCS fetal membranes.

Conclusion: Components of the apoptotic signalling pathways and MMP-9 may play a role in rupture and labour. Non-labouring SCS fetal membranes display altered morphology and altered apoptotic biochemical characteristics in preparation for labour, while the laboured SOR displays unique MMP characteristics.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
Official 2014 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 5 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 10 Nov 2013, 10:48:20 EST by System User on behalf of UQ Centre for Clinical Research