Plasma omega-3 and omega-6 concentrations and risk of cutaneous basal and squamous cell carcinomas in Australian adults

Wallingford, Sarah C., Hughes, Maria Celia, Green, Adele C. and van der Pols, Jolieke C. (2013) Plasma omega-3 and omega-6 concentrations and risk of cutaneous basal and squamous cell carcinomas in Australian adults. Cancer Epidemiology Biomarkers & Prevention, 22 10: 1900-1905. doi:10.1158/1055-9965.EPI-13-0434


Author Wallingford, Sarah C.
Hughes, Maria Celia
Green, Adele C.
van der Pols, Jolieke C.
Title Plasma omega-3 and omega-6 concentrations and risk of cutaneous basal and squamous cell carcinomas in Australian adults
Journal name Cancer Epidemiology Biomarkers & Prevention   Check publisher's open access policy
ISSN 1055-9965
1538-7755
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1158/1055-9965.EPI-13-0434
Volume 22
Issue 10
Start page 1900
End page 1905
Total pages 6
Place of publication Philadelphia, PA United States
Publisher American Association for Cancer Research
Language eng
Formatted abstract
Laboratory-based evidence suggests that omega-3 and omega-6 polyunsaturated fatty acids may affect skin photocarcinogenesis, but epidemiologic evidence is inconsistent. In 1,191 White Australian adults, we prospectively investigated associations between baseline plasma concentrations of omega-3 and omega-6 fatty acids and cutaneous basal cell carcinomas (BCC) and squamous cell carcinomas (SCC). Relative risks (RR) and 95% confidence intervals (CI) were estimated on the basis of number of histologically confirmed tumors diagnosed during follow-up (1997-2007). Plasma eicosapentaenoic acid (EPA) concentrations and omega-3/-6 ratio showed significant inverse associations with SCC tumors, comparing higher tertiles with the lowest, in age- and sex-adjusted models (Ptrend = 0.02 and 0.03, respectively) which weakened after adjustment for past sun exposure. Associations between EPA and SCC were stronger among participants with a history of skin cancer at baseline (n = 378; highest vs. lowest tertile: RR = 0.50; 95% CI, 0.28-0.92; Ptrend = 0.01). Total omega-6 was inversely associated withBCCtumors in multivariate models (P=0.04; highest vs. lowest tertile:RR=0.71; 95% CI, 0.51-0.99), and more strongly in the subgroup with past skin cancer. Linoleic and linolenic acids were also inversely associated with BCC occurrence in this subgroup. When fatty acids were analyzed as continuous variables, however, there was no evidence of any linear or nonlinear associations. This study provides some support for reduced skin cancer risk with high plasma concentrations of omega-3 and omega-6 fatty acids, but results depended on how fatty acid data were modeled. Further investigation of these associations in larger datasets is needed.
Keyword Polyunsaturated Fatty acids
Nonmelanoma skin cancer
Eicosapentaenoic Acid
Photocarcinogenesis
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
 
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