Candidate genes and biological pathways associated with carcass quality traits in beef cattle

Karisa, B. K., Thomson, J., Wang, Z., Bruce, H. L., Plastow, G. S. and Moore, S. S. (2013) Candidate genes and biological pathways associated with carcass quality traits in beef cattle. Canadian Journal of Animal Science, 93 3: 295-306. doi:10.4141/CJAS2012-136

Author Karisa, B. K.
Thomson, J.
Wang, Z.
Bruce, H. L.
Plastow, G. S.
Moore, S. S.
Title Candidate genes and biological pathways associated with carcass quality traits in beef cattle
Journal name Canadian Journal of Animal Science   Check publisher's open access policy
ISSN 0008-3984
Publication date 2013-09-01
Sub-type Article (original research)
DOI 10.4141/CJAS2012-136
Volume 93
Issue 3
Start page 295
End page 306
Total pages 12
Place of publication Ottawa, ON Canada
Publisher Agricultural Institute of Canada
Language eng
Formatted abstract
The objective of this study was to use the candidate gene approach to identify the genes associated with carcass quality traits in beef cattle steers at the University of Alberta Ranch at Kinsella, Canada. This approach involved identifying positional candidate genes and prioritizing them according to their functions into functional candidate genes before performing statistical association analysis. The positional candidate genes and single nucleotide polymorphisms (SNP) were identified from previously reported quantitative trait loci for component traits including body weight, average daily gain, metabolic weight, feed efficiency and energy balance. Positional candidate genes were then prioritized into functional candidate genes according to the associated gene ontology terms and their functions. A total of 116 genes were considered functional candidate genes and 117 functional SNPs were genotyped and used for multiple marker association analysis using ASReml®. Seven SNPs were significantly associated with various carcass quality traits (P≤0.005). The significant genes were associated with biological processes such as fat, glucose, protein and steroid metabolism, growth, energy utilization and DNA transcription and translation as inferred from the protein knowledgebase (UniprotKB). Gene network analysis indicated significant involvement of biological processes related to fat and steroid metabolism and regulation of transcription and translation of DNA.
Keyword Beef cattle
Carcass traits
Gene networks
Residual feed intake
Meat Quality
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Queensland Alliance for Agriculture and Food Innovation
Official 2014 Collection
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