Attachment of poly(acrylic acid) to 3-aminopropyltriethoxysilane hydroxyapatite

Goonaseker, Chandhi S., Jack, Kevin S., Cooper-White, Justin J. and Grondahl, Lisbeth (2013) Attachment of poly(acrylic acid) to 3-aminopropyltriethoxysilane hydroxyapatite. Journal of Materials Chemistry B, 1 42: 5842-5852. doi:10.1039/c3tb21110j

Author Goonaseker, Chandhi S.
Jack, Kevin S.
Cooper-White, Justin J.
Grondahl, Lisbeth
Title Attachment of poly(acrylic acid) to 3-aminopropyltriethoxysilane hydroxyapatite
Journal name Journal of Materials Chemistry B   Check publisher's open access policy
ISSN 2050-750X
Publication date 2013-01-01
Sub-type Article (original research)
DOI 10.1039/c3tb21110j
Open Access Status Not Open Access
Volume 1
Issue 42
Start page 5842
End page 5852
Total pages 11
Place of publication Cambridge, United Kingdom
Publisher R S C Publications
Language eng
Formatted abstract
Nano-sized hydroxyapatite (HAP) is of interest in biomaterials science due to its similarity to bone mineral. In this study, HAP modification using 3-aminopropyltriethoxysilane (APTES) was carried out in toluene and the effect of reaction time and curing temperature on the surface layers formed was investigated through X-ray photoelectron spectroscopy, Fourier transform infrared (FT-IR) and solid-state nuclear magnetic resonance (NMR) spectroscopy. It is shown that the chemical composition is strongly influenced by the curing temperature; with low temperatures of 50 and 100 °C resulting in a fully condensed APTES layer, an intermediate temperature of 150 °C causing partial oxidation of the surface layer with the conversion of some amine functionality to amides while curing at a temperature of 200 °C additionally leads to thermal decomposition of the silane layer and a loss of the pendent amine groups. However, the stability of these particles in aqueous solution indicated a loss of the silane layer for samples cured at 150 °C or less and it is concluded that there is a trade-off between the availability of functionality for further chemical grafting and the stability for these APTES-modified HAP materials. Subsequent attachment of the polyelectrolyte poly(acrylic acid) (PAA) via both ionic interaction and covalent bonding using carbodiimide chemistry resulted in particles with more negative zeta potentials (-27 to -18 mV) compared to pure HAP, which were stable to dispersion in aqueous solution, both with respect to their chemical composition at the particle surface and to aggregation.
Keyword Surface Modification
Nanocrystalline Hydroxyapatite
Grafting Polymerization
Barium Hydroxyapatites
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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