Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii

Liu, Xinru, Song, Fuhang, Ma, Li, Chen, Caixia, Xiao, Xue, Ren, Biao, Liu, Xueting, Dai, Huanqin, Piggott, Andrew M., Av-Gay, Yossef, Zhang, Lixin and Capon, Robert J. (2013) Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii. Tetrahedron Letters, 54 45: 6081-6083. doi:10.1016/j.tetlet.2013.08.137


Author Liu, Xinru
Song, Fuhang
Ma, Li
Chen, Caixia
Xiao, Xue
Ren, Biao
Liu, Xueting
Dai, Huanqin
Piggott, Andrew M.
Av-Gay, Yossef
Zhang, Lixin
Capon, Robert J.
Title Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii
Formatted title
Sydowiols A-C: Mycobacterium tuberculosis protein tyrosine phosphatase inhibitors from an East China Sea marine-derived fungus, Aspergillus sydowii
Journal name Tetrahedron Letters   Check publisher's open access policy
ISSN 0040-4039
1873-3581
Publication date 2013-11-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.tetlet.2013.08.137
Open Access Status Not yet assessed
Volume 54
Issue 45
Start page 6081
End page 6083
Total pages 3
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Abstract Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (1-3), and two known bis-pyrogallol ethers, violaceols I (4) and 11 (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA). (C) 2013 Elsevier Ltd. All rights reserved.
Formatted abstract
Chemical analysis of an East China Sea marine-derived fungus, Aspergillus sydowii (MF357) returned three new tris-pyrogallol ethers, sydowiols A-C (1-3), and two known bis-pyrogallol ethers, violaceols I (4) and II (5). Structures were assigned on the basis of detailed spectroscopic analysis and by consideration of symmetry. Sydowiols A (1) and C (3) were responsible for the inhibitory activity detected in the crude fungal extract against Mycobacterium tuberculosis protein tyrosine phosphatase A (PtpA).
Keyword Marine-derived fungus
Aspergillus sydowii
Mycobacterium tuberculosis
Protein tyrosine phosphatase A (PtpA)
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 2013CB734000
30901849
XDA04074000
2011ZX11102011-11
LP120100088
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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