Clinical characteristics, etiology and antimicrobial susceptibility among overweight and obese individuals with diarrhea: observed at a large diarrheal disease hospital, Bangladesh

Das, Sumon Kumar, Chisti, Mohammod Jobayer, Huq, Sayeeda, Malek, Mohammad Abdul, Vanderlee, Lana, Kaur, Guddu, Salam, Mohammed Abdus, Ahmed, Tahmeed, Faruque, Abu Syed Golam and Al Mamun, Abdullah (2013) Clinical characteristics, etiology and antimicrobial susceptibility among overweight and obese individuals with diarrhea: observed at a large diarrheal disease hospital, Bangladesh. PLoS One, 8 8: e70402.1-e70402.10. doi:10.1371/journal.pone.0070402

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Author Das, Sumon Kumar
Chisti, Mohammod Jobayer
Huq, Sayeeda
Malek, Mohammad Abdul
Vanderlee, Lana
Kaur, Guddu
Salam, Mohammed Abdus
Ahmed, Tahmeed
Faruque, Abu Syed Golam
Al Mamun, Abdullah
Title Clinical characteristics, etiology and antimicrobial susceptibility among overweight and obese individuals with diarrhea: observed at a large diarrheal disease hospital, Bangladesh
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-08-01
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0070402
Open Access Status DOI
Volume 8
Issue 8
Start page e70402.1
End page e70402.10
Total pages 11
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Formatted abstract
Background: The present study aimed to determine the clinical characteristics and etiology of overweight and obese (OO)
individuals with diarrhea attending an urban Dhaka Hospital, International Centre for Diarrheal Disease Research (icddr,b),
Bangladesh.

Methods: Total of 508 under-5 children, 96 individuals of 5–19 years and 1331 of .19 years were identified as OO from the
Diarrheal Disease Surveillance System (DDSS) between 1993–2011. Two comparison groups such as well-nourished and
malnourished individuals from respective age stratums were selected.

Results:
Isolation rate of rotavirus was higher among OO under-5 children compared to malnourished group (46% vs. 28%).  Rotavirus infection among OO individuals aged 5–19 years (9% vs. 3%) (9% vs. 3%) and .19 years (6% vs. 4%) (6% vs. 3%) was higher compared to well-nourished and malnourished children. Conversely, Vibrio cholerae was lower among all OO age groups compared to well-nourished and malnourished ones. Shigella (4% vs. 6%) (4% vs. 8%), and Campylobacter (3% vs.5%) (3% vs. 5%) were lower only among OO in .19 years individuals compared to their counterparts of the same age stratum. Salmonella was similarly isolated in all age strata and nutritional groups. In multinomial logistic regression among under-5 children, significant association was observed only with use of antimicrobials at home [OR-1.97] and duration of hospital stay [OR-0.68]. For individuals aged 5–19 years, use of antimicrobials at home (OR-1.83), some or severe dehydration (OR-3.12), having received intravenous saline (OR-0.46) and rotavirus diarrhea (OR-2.96) were found to be associated with OO respectively. Moreover, significant associations were also found for duration of diarrhea before coming to hospital (.24 hours) (OR-1.24), Shigella (OR-0.46), and Campylobacter (OR-0.58) among .19 years OO individuals along with other associated co-variates in 5–19 years group (all p,0.05).

Conclusion and significance: Higher proportion of OO were infected with rotavirus and a greater proportion of them used
antimicrobials before coming to the hospital.
Keyword Developing Countries
Systematic Analysis
Child Mortality
National Causes
Weight
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Public Health Publications
 
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