Effects of ovariohysterectomy on prostaglandin F-2 alpha-induced nesting behaviour in pigs

Burne, THJ, Murfitt, PJE and Gilbert, CL (2001) Effects of ovariohysterectomy on prostaglandin F-2 alpha-induced nesting behaviour in pigs. Physiology & Behavior, 74 1-2: 145-152. doi:10.1016/S0031-9384(01)00536-4


Author Burne, THJ
Murfitt, PJE
Gilbert, CL
Title Effects of ovariohysterectomy on prostaglandin F-2 alpha-induced nesting behaviour in pigs
Journal name Physiology & Behavior   Check publisher's open access policy
ISSN 0031-9384
Publication date 2001-09-01
Year available 2001
Sub-type Article (original research)
DOI 10.1016/S0031-9384(01)00536-4
Open Access Status Not yet assessed
Volume 74
Issue 1-2
Start page 145
End page 152
Total pages 8
Place of publication OXFORD
Publisher PERGAMON-ELSEVIER SCIENCE LTD
Language eng
Abstract Exogenously administered prostaglandin (PG) F-2 alpha induces behaviour similar to prepartum nest building in pregnant, pseudopregnant and nonpregnant female postpubescent pigs (Sus scrofa). These effects may be regulated by PGF(2 alpha)-induced endocrine changes within the reproductive tract, such as those that initiate luteolysis. This study investigated the short-term effects of ovariohysterectomy on PGF(2 alpha)-induced nesting behaviour in nonpregnant females. Cyclic 9-month-old virgin female pigs (gilts) received an oral dose (20 mg/day) of a synthetic progestogen (altrenogest; Regumate porcine, Hoechst, Milton Keynes, UK) for 18-21 days to synchronize oestrus. The gilts were then ovariohysterectomized (n = 8) or sham-operated (n = 7) on Days 3 - 8 after oestrus. They were housed individually and initially subjected to a series of control behavioural tests to establish the effect of ovariohysterectomy on their responses to the experimenters, novel objects, straw bedding and space restriction. Ovariohysterectomized gilts had a shorter latency to approach the experimenters than sham-operated animals, but there were no differences in their responses to a novel object, straw bedding or space restriction. Twelve to 16 days after oestrus, corresponding to the midluteal phase in sham-operated gilts, they were treated intramuscularly with 15 mg PGF(2 alpha) (0.12 mg/kg, dinoprost; Lutalyse, Upjohn, Crawley, UK). PGF(2 alpha) treatment induced a significant increase in straw gathering in ovariohysterectornized but not in sham-operated gilts. Other nesting behaviours, including rooting and pawing at straw, were induced in all animals. These results show that the uterus and ovaries are not required for the expression of PGF(2 alpha)-induced nesting behaviour and the removal of the reproductive tract appears to have facilitated increased levels of gathering. This suggests that PGF(2 alpha) induces luteolysis and nest building separately, and that PGF(2 alpha) or a metabolite, may act centrally to mediate directly its effects on prepartum nest building in the pig. (C) 2001 Elsevier Science Inc. All rights reserved.
Keyword prostaglandin F-2 alpha
pig
reproductive tract
nest building
behaviour
Pseudopregnant Gilts
Building Behavior
Space Restriction
Domestic Sows
Progesterone
Prolactin
Responses
Plasma
Brain
Swine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: ResearcherID Downloads - Archived
 
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