Repetition suppression and plasticity in the human brain

Garrido, Marta I., Kilner, James M., Kiebel, Stefan J., Stephan, Klaas E., Baldeweg, Torsten and Friston, Karl J. (2009) Repetition suppression and plasticity in the human brain. Neuroimage, 48 1: 269-279. doi:10.1016/j.neuroimage.2009.06.034

Author Garrido, Marta I.
Kilner, James M.
Kiebel, Stefan J.
Stephan, Klaas E.
Baldeweg, Torsten
Friston, Karl J.
Title Repetition suppression and plasticity in the human brain
Journal name Neuroimage   Check publisher's open access policy
ISSN 1053-8119
Publication date 2009-10-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2009.06.034
Open Access Status Not yet assessed
Volume 48
Issue 1
Start page 269
End page 279
Total pages 11
Place of publication Amsterdam, The Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
The suppression of neuronal responses to a repeated event is a ubiquitous phenomenon in neuroscience. However, the underlying mechanisms remain largely unexplored. The aim of this study was to examine the temporal evolution of experience-dependent changes in connectivity induced by repeated stimuli. We recorded event-related potentials (ERPs) during frequency changes of a repeating tone. Bayesian inversion of dynamic causal models (DCM) of ERPs revealed systematic repetition-dependent changes in both intrinsic and extrinsic connections, within a hierarchical cortical network. Critically, these changes occurred very quickly, over inter-stimulus intervals that implicate short-term synaptic plasticity. Furthermore, intrinsic (within-source) connections showed biphasic changes that were much faster than changes in extrinsic (between-source) connections, which decreased monotonically with repetition. This study shows that auditory perceptual learning is associated with repetition-dependent plasticity in the human brain. It is remarkable that distinct changes in intrinsic and extrinsic connections could be quantified so reliably and non-invasively using EEG. 
Keyword Connectivity
Perceptual learning
Dynamic Causal Models
Neural Mass Model
Auditory cortex
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID SFRH/BD/13481/2003
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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