Functional Evidence for a Dual Route to Amygdala

Garrido, Marta I., Barnes, Gareth R., Sahani, Maneesh and Dolan, Raymond J. (2012) Functional Evidence for a Dual Route to Amygdala. Current Biology, 22 2: 129-134. doi:10.1016/j.cub.2011.11.056


Author Garrido, Marta I.
Barnes, Gareth R.
Sahani, Maneesh
Dolan, Raymond J.
Title Functional Evidence for a Dual Route to Amygdala
Journal name Current Biology   Check publisher's open access policy
ISSN 0960-9822
1879-0445
Publication date 2012-01-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.cub.2011.11.056
Open Access Status Not Open Access
Volume 22
Issue 2
Start page 129
End page 134
Total pages 6
Place of publication Cambridge, MA United States
Publisher Cell Press
Language eng
Formatted abstract
 The amygdala plays a central role in evaluating the behavioral importance of sensory information. Anatomical subcortical pathways provide direct input to the amygdala from early sensory systems and may support an adaptively valuable rapid appraisal of salient information [1, 2 and 3]. However, the functional significance of these subcortical inputs remains controversial [4]. We recorded magnetoencephalographic activity evoked by tones in the context of emotionally valent faces and tested two competing biologically motivated dynamic causal models [5 and 6] against these data: the dual and cortical models. The dual model comprised two parallel (cortical and subcortical) routes to the amygdala, whereas the cortical model excluded the subcortical path. We found that neuronal responses elicited by salient information were better explained when a subcortical pathway was included. In keeping with its putative functional role of rapid stimulus appraisal, the subcortical pathway was most important early in stimulus processing. However, as often assumed, its action was not limited to the context of fear, pointing to a more widespread information processing role. Thus, our data supports the idea that an expedited evaluation of sensory input is best explained by an architecture that involves a subcortical path to the amygdala.
Keyword Emotional Faces
Neural Responses
Auditory cortex
Brain
Fear
Magnetoencephalography
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID 091593/Z/10/Z
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
 
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