Preserved Feedforward But Impaired Top-Down Processes in the Vegetative State

Boly, Melanie, Garrido, Marta Isabel, Gosseries, Olivia, Bruno, Marie-Aurelie, Boveroux, Pierre, Schnakers, Caroline, Massimini, Marcello, Litvak, Vladimir, Laureys, Steven and Friston, Karl (2011) Preserved Feedforward But Impaired Top-Down Processes in the Vegetative State. Science, 332 6031: 858-862. doi:10.1126/science.1202043

Author Boly, Melanie
Garrido, Marta Isabel
Gosseries, Olivia
Bruno, Marie-Aurelie
Boveroux, Pierre
Schnakers, Caroline
Massimini, Marcello
Litvak, Vladimir
Laureys, Steven
Friston, Karl
Title Preserved Feedforward But Impaired Top-Down Processes in the Vegetative State
Journal name Science   Check publisher's open access policy
ISSN 0036-8075
Publication date 2011-05-01
Year available 2011
Sub-type Article (original research)
DOI 10.1126/science.1202043
Open Access Status Not yet assessed
Volume 332
Issue 6031
Start page 858
End page 862
Total pages 5
Place of publication Washington, DC United States
Publisher American Association for the Advancement of Science
Language eng
Formatted abstract
Frontoparietal cortex is involved in the explicit processing (awareness) of stimuli. Frontoparietal activation has also been found in studies of subliminal stimulus processing. We hypothesized that an impairment of top-down processes, involved in recurrent neuronal message-passing and the generation of long-latency electrophysiological responses, might provide a more reliable correlate of consciousness in severely brain-damaged patients, than frontoparietal responses. We measured effective connectivity during a mismatch negativity paradigm and found that the only significant difference between patients in a vegetative state and controls was an impairment of backward connectivity from frontal to temporal cortices. This result emphasizes the importance of top-down projections in recurrent processing that involve high-order associative cortices for conscious perception. 
Keyword Minimally Conscious State
Event Related Potentials
Mismatch Negativity
Q-Index Code C1
Q-Index Status Provisional Code
Grant ID ARC 06/11-340
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Brain Institute Publications
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Citation counts: TR Web of Science Citation Count  Cited 194 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 219 times in Scopus Article | Citations
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