The mismatch negativity: a review of underlying mechanisms

Garrido, Marta I., Kilner, James M., Stephan, Klaas E. and Friston, Karl J. (2009) The mismatch negativity: a review of underlying mechanisms. Clinical Neurophysiology, 120 3: 453-463. doi:10.1016/j.clinph.2008.11.029

Author Garrido, Marta I.
Kilner, James M.
Stephan, Klaas E.
Friston, Karl J.
Title The mismatch negativity: a review of underlying mechanisms
Journal name Clinical Neurophysiology   Check publisher's open access policy
ISSN 1388-2457
Publication date 2009-03-01
Year available 2009
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.clinph.2008.11.029
Open Access Status Not yet assessed
Volume 120
Issue 3
Start page 453
End page 463
Total pages 11
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier
Language eng
Formatted abstract
The mismatch negativity (MMN) is a brain response to violations of a rule, established by a sequence of sensory stimuli (typically in the auditory domain) [Näätänen R. Attention and brain function. Hillsdale, NJ: Lawrence Erlbaum; 1992]. The MMN reflects the brain’s ability to perform automatic comparisons between consecutive stimuli and provides an electrophysiological index of sensory learning and perceptual accuracy. Although the MMN has been studied extensively, the neurophysiological mechanisms underlying the MMN are not well understood. Several hypotheses have been put forward to explain the generation of the MMN; amongst these accounts, the “adaptation hypothesis” and the “model adjustment hypothesis” have received the most attention. This paper presents a review of studies that focus on neuronal mechanisms underlying the MMN generation, discusses the two major explanatory hypotheses, and proposes predictive coding as a general framework that attempts to unify both.
Keyword Mismatch negativity (MMN)
Event-related potential (ERP)
Mechanistic models
Cortical networks
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Queensland Brain Institute Publications
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