Impact of changed positive and negative task-related brain activity on word-retrieval in aging

Meinzer, Marcus, Seeds, Lauren, Flaisch, Tobias, Harnish, Stacy, Cohen, Matt L., McGregor, Keith, Conway, Tim, Benjamin, Michelle and Crosson, Bruce (2012) Impact of changed positive and negative task-related brain activity on word-retrieval in aging. Neurobiology of Aging, 33 4: 656-669. doi:10.1016/j.neurobiolaging.2010.06.020

Author Meinzer, Marcus
Seeds, Lauren
Flaisch, Tobias
Harnish, Stacy
Cohen, Matt L.
McGregor, Keith
Conway, Tim
Benjamin, Michelle
Crosson, Bruce
Title Impact of changed positive and negative task-related brain activity on word-retrieval in aging
Journal name Neurobiology of Aging   Check publisher's open access policy
ISSN 0197-4580
Publication date 2012-04-01
Year available 2012
Sub-type Article (original research)
DOI 10.1016/j.neurobiolaging.2010.06.020
Volume 33
Issue 4
Start page 656
End page 669
Total pages 14
Place of publication Philadelphia, PA United States
Publisher Elsevier Inc.
Language eng
Formatted abstract
 Previous functional imaging studies that compared activity patterns in older and younger adults during nonlinguistic tasks found evidence for 2 phenomena: older participants usually show more pronounced task-related positive activity in the brain hemisphere that is not dominant for the task and less pronounced negative task-related activity in temporo-parietal and midline brain regions. The combined effects of these phenomena and the impact on word retrieval, however, have not yet been assessed. We used functional magnetic resonance imaging to explore task-related positive (active task > baseline) and negative activity (baseline > active task) during semantic and phonemic verbal fluency tasks. Increased right frontal positive activity during the semantic task and reduced negative activity in the right hemisphere during both tasks was associated with reduced performance in older subjects. No substantial relationship between changes in positive and negative activity was observed in the older participants, pointing toward 2 partially independent but potentially co-occurring processes. Underlying causes of the observed functional network inefficiency during word retrieval in older adults need to be determined in the future.
Keyword Functional magnetic resonance imaging
Language production
Verbal fluency
Default network
Age Related Changes
Alzheimers Disease
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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