Imaging short- and long-term training success in chronic aphasia

Menke, Ricarda, Meinzer, Marcus, Kugel, Harald, Deppe, Michael, Baumgaertner, Annette, Schiffbauer, Hagen, Thomas, Marion, Kramer, Kira, Lohmann, Hubertus, Floeel, Agnes, Knecht, Stefan and Breitenstein, Caterina (2009) Imaging short- and long-term training success in chronic aphasia. BMC Neuroscience, 10 . doi:10.1186/1471-2202-10-118


Author Menke, Ricarda
Meinzer, Marcus
Kugel, Harald
Deppe, Michael
Baumgaertner, Annette
Schiffbauer, Hagen
Thomas, Marion
Kramer, Kira
Lohmann, Hubertus
Floeel, Agnes
Knecht, Stefan
Breitenstein, Caterina
Title Imaging short- and long-term training success in chronic aphasia
Journal name BMC Neuroscience   Check publisher's open access policy
ISSN 1471-2202
Publication date 2009-09-01
Year available 2009
Sub-type Article (original research)
DOI 10.1186/1471-2202-10-118
Open Access Status DOI
Volume 10
Total pages 13
Place of publication London, United Kingdom
Publisher BioMed Central Ltd.
Language eng
Formatted abstract
Background
To date, functional imaging studies of treatment-induced recovery from chronic aphasia only assessed short-term treatment effects after intensive language training. In the present study, we show with functional magnetic resonance imaging (fMRI), that different brain regions may be involved in immediate versus long-term success of intensive language training in chronic post-stroke aphasia patients.

Results
Eight patients were trained daily for three hours over a period of two weeks in naming of concrete objects. Prior to, immediately after, and eight months after training, patients overtly named trained and untrained objects during event-related fMRI. On average the patients improved from zero (at baseline) to 64.4% correct naming responses immediately after training, and treatment success remained highly stable at follow-up. Regression analyses showed that the degree of short-term treatment success was predicted by increased activity (compared to the pretraining scan) bilaterally in the hippocampal formation, the right precuneus and cingulate gyrus, and bilaterally in the fusiform gyri. A different picture emerged for long-term training success, which was best predicted by activity increases in the right-sided Wernicke's homologue and to a lesser degree in perilesional temporal areas.

Conclusion
The results show for the first time that treatment-induced language recovery in the chronic stage after stroke is a dynamic process. Initially, brain regions involved in memory encoding, attention, and multimodal integration mediated treatment success. In contrast, long-term treatment success was predicted mainly by activity increases in the so-called 'classical' language regions. The results suggest that besides perilesional and homologue language-associated regions, functional integrity of domain-unspecific memory structures may be a prerequisite for successful (intensive) language interventions. 
Keyword Language Therapy
Anomia Treatment
Recovery
Stroke
Activation
Fmri
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 53 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 53 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 01 Nov 2013, 21:52:18 EST by System User on behalf of UQ Centre for Clinical Research