Enhanced Rapid-Onset Cortical Plasticity in CADASIL as a Possible Mechanism of Preserved Cognition

List, Jonathan, Duning, Thomas, Meinzer, Marcus, Kuerten, Julia, Schirmacher, Anja, Deppe, Michael, Evers, Stefan, Young, Peter and Floeel, Agnes (2011) Enhanced Rapid-Onset Cortical Plasticity in CADASIL as a Possible Mechanism of Preserved Cognition. Cerebral Cortex, 21 12: 2774-2787. doi:10.1093/cercor/bhr071

Author List, Jonathan
Duning, Thomas
Meinzer, Marcus
Kuerten, Julia
Schirmacher, Anja
Deppe, Michael
Evers, Stefan
Young, Peter
Floeel, Agnes
Title Enhanced Rapid-Onset Cortical Plasticity in CADASIL as a Possible Mechanism of Preserved Cognition
Journal name Cerebral Cortex   Check publisher's open access policy
ISSN 1047-3211
Publication date 2011-12-01
Year available 2011
Sub-type Article (original research)
DOI 10.1093/cercor/bhr071
Open Access Status Not Open Access
Volume 21
Issue 12
Start page 2774
End page 2787
Total pages 14
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Formatted abstract
schemic small vessel disease (SVD) may lead to cognitive impairment, but cognitive deficits with a given burden of SVD vary significantly. The underlying mechanisms of impaired or preserved cognition are unknown. Here, we investigated the impact of ischemic SVD on rapid-onset cortical plasticity, as induced with a paired-associative stimulation protocol. To exclude concomitant effects of aging, we examined 12 middle-aged patients (48.3 ± 8.3 years) with cerebral autosomal dominant arteriopathy with subcortical infarctions and leucoencephalopathy (CADASIL) who suffered from severe ischemic SVD and a group of 12 age-matched controls (49.9 ± 8.3 years). Cognitive status, motor performance and learning, and motor cortex excitability in response to cathodal transcranial direct current stimulation (ctDCS) were assessed. White matter integrity was analyzed by conventional magnetic resonance imaging and diffusion tensor imaging. We found that cognitive and motor functions were largely preserved in CADASIL patients, while rapid-onset cortical plasticity was significantly higher in the CADASIL group compared with controls (repeated measures analysis of variance [group × time] interaction: P = 0.03). This finding was even more pronounced in patients with higher white matter lesion load. ctDCS revealed no evidence of cortical dysplasticity. We conclude that increased rapid-onset cortical plasticity may contribute to largely preserved cognitive and motor function despite extensive ischemic SVD. 
Keyword Diffusion tensor imaging
Ischemic small vessel disease
Transcranial Magnetic Stimulation
Paired Associative Stimulation
Human Motor Cortex
Condition Causing Stroke
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 20 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 21 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 01 Nov 2013, 21:50:08 EST by System User on behalf of UQ Centre for Clinical Research