Recreating kidney progenitors from pluripotent cells

Takasato, Minoru, Maier, Barbara and Little, Melissa H. (2013) Recreating kidney progenitors from pluripotent cells. Pediatric Nephrology, 29 4: 543-552. doi:10.1007/s00467-013-2592-7

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Author Takasato, Minoru
Maier, Barbara
Little, Melissa H.
Title Recreating kidney progenitors from pluripotent cells
Journal name Pediatric Nephrology   Check publisher's open access policy
ISSN 0931-041X
Publication date 2013-09-13
Year available 2014
Sub-type Fully published paper
DOI 10.1007/s00467-013-2592-7
Open Access Status Not Open Access
Volume 29
Issue 4
Start page 543
End page 552
Total pages 10
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
Access to human pluripotent cells theoretically provides a renewable source of cells that can give rise to any required cell type for use in cellular therapy or bioengineering. However, successfully directing this differentiation remains challenging for most desired endpoints cell type, including renal cells. This challenge is compounded by the difficulty in identifying the required cell type in vitro and the multitude of renal cell types required to build a kidney. Here we review our understanding of how the embryo goes about specifying the cells of the kidney and the progress to date in adapting this knowledge for the recreation of nephron progenitors and their mature derivatives from pluripotent cells.
Keyword Kidney development
Embryonic stem cell
Directed differentiation
Kidney progenitor
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID SRI110001002
Institutional Status UQ
Additional Notes Published online: 13 September 2013

Document type: Journal Article
Sub-type: Fully published paper
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 8 times in Scopus Article | Citations
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Created: Fri, 01 Nov 2013, 01:06:58 EST by Susan Allen on behalf of Institute for Molecular Bioscience