Stromal cells in tissue homeostasis: balancing regeneration and fibrosis

Rabelink, Ton J. and Little, Melissa H. (2013) Stromal cells in tissue homeostasis: balancing regeneration and fibrosis. Nature Reviews: Nephrology, 9 12: 747-753. doi:10.1038/nrneph.2013.152

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Author Rabelink, Ton J.
Little, Melissa H.
Title Stromal cells in tissue homeostasis: balancing regeneration and fibrosis
Journal name Nature Reviews: Nephrology   Check publisher's open access policy
ISSN 1759-5061
1759-507X
Publication date 2013-08-13
Year available 2013
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrneph.2013.152
Open Access Status Not Open Access
Volume 9
Issue 12
Start page 747
End page 753
Total pages 7
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
The ageing population and the increasing prevalence of noncommunicable diseases such as diabetes and hypertension have led to an increased prevalence of chronic kidney disease. The generation of de novo kidney tissue from embryonic tissue and stem cells using tissue engineering approaches is being explored as an alternative to renal replacement therapy for treating the disease. It is, however, becoming clear that resident cells can not only induce fibrotic repair, but can also restore damaged kidney tissue. Mobilizing this innate capacity of the kidney to regenerate is of particular interest in the prevention of irreversible kidney failure. A novel concept is that the interaction of interstitial stromal cells with the local immune system may regulate tissue homeostasis and the balance between tissue repair and fibrosis. Mesenchymal stromal cells (MSCs), in particular, may enhance the intrinsic reparative capabilities of the kidney. This Perspectives article considers the innate regenerative potential of the kidney in the context of ongoing studies of MSC therapy.
Keyword Urology & Nephrology
Urology & Nephrology
UROLOGY & NEPHROLOGY
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 305436
APP1054985
Institutional Status UQ
Additional Notes Published online 13 August 2013

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2014 Collection
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 10 times in Scopus Article | Citations
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Created: Fri, 01 Nov 2013, 01:04:12 EST by Susan Allen on behalf of Institute for Molecular Bioscience