The genome of the hydatid tapeworm Echinococcus granulosus

Zheng, Huajun, Zhang, Wenbao, Zhang, Liang, Zhang, Zhuangzhi, Li, Jun, Lu, Gang, Zhu, Yongqiang, Wang, Yuezhu, Huang, Yin, Liu, Jing, Kang, Hui, Chen, Jie, Wang, Lijun, Chen, Aojun, Yu, Shuting, Gao, Zhengchao, Jin, Lei, Gu, Wenyi, Wang, Zhiqin, Zhao, Li, Shi, Baoxin, Wen, Hao, Lin, Renyong, Jones, Malcolm K., Brejova, Brona, Vinar, Tomas, Zhao, Guoping, McManus, Donald P., Chen, Zhu, Zhou, Yan and Wang, Shengyue (2013) The genome of the hydatid tapeworm Echinococcus granulosus. Nature Genetics, 45 10: 1168-1177. doi:10.1038/ng.2757


Author Zheng, Huajun
Zhang, Wenbao
Zhang, Liang
Zhang, Zhuangzhi
Li, Jun
Lu, Gang
Zhu, Yongqiang
Wang, Yuezhu
Huang, Yin
Liu, Jing
Kang, Hui
Chen, Jie
Wang, Lijun
Chen, Aojun
Yu, Shuting
Gao, Zhengchao
Jin, Lei
Gu, Wenyi
Wang, Zhiqin
Zhao, Li
Shi, Baoxin
Wen, Hao
Lin, Renyong
Jones, Malcolm K.
Brejova, Brona
Vinar, Tomas
Zhao, Guoping
McManus, Donald P.
Chen, Zhu
Zhou, Yan
Wang, Shengyue
Title The genome of the hydatid tapeworm Echinococcus granulosus
Formatted title
The genome of the hydatid tapeworm Echinococcus granulosus
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1038/ng.2757
Open Access Status DOI
Volume 45
Issue 10
Start page 1168
End page 1177
Total pages 10
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Subject 1311 Genetics
Abstract Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease is difficult to diagnose, treat and control. We present a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 genes. Comparisons with the genome sequences from other taxa show that E. granulosus has acquired a spectrum of genes, including the EgAgB family, whose products are secreted by the parasite to interact and redirect host immune responses. We also find that genes in bile salt pathways may control the bidirectional development of E. granulosus, and sequence differences in the calcium channel subunit EgCa v β 1 may be associated with praziquantel sensitivity. Our study offers insights into host interaction, nutrient acquisition, strobilization, reproduction, immune evasion and maturation in the parasite and provides a platform to facilitate the development of new, effective treatments and interventions for echinococcosis control.
Formatted abstract
Cystic echinococcosis (hydatid disease), caused by the tapeworm E. granulosus, is responsible for considerable human morbidity and mortality. This cosmopolitan disease is difficult to diagnose, treat and control. We present a draft genomic sequence for the worm comprising 151.6 Mb encoding 11,325 genes. Comparisons with the genome sequences from other taxa show that E. granulosus has acquired a spectrum of genes, including the EgAgB family, whose products are secreted by the parasite to interact and redirect host immune responses. We also find that genes in bile salt pathways may control the bidirectional development of E. granulosus, and sequence differences in the calcium channel subunit EgCavβ1 may be associated with praziquantel sensitivity. Our study offers insights into host interaction, nutrient acquisition, strobilization, reproduction, immune evasion and maturation in the parasite and provides a platform to facilitate the development of new, effective treatments and interventions for echinococcosis control.
Keyword Echinococcosis
Echinococcus
Genomics
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 2010CB534906
30760185
10XD1403200
2012AA020409
IRT1181
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Geography, Planning and Environmental Management Publications
Official 2014 Collection
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 80 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 86 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 31 Oct 2013, 23:20:49 EST by Dr Malcolm Jones on behalf of School of Geography, Planning & Env Management