The cancer biology of whole-chromosome instability

Duijf, P. H. G. and Benezra, R. (2013) The cancer biology of whole-chromosome instability. Oncogene, 32 40: 4727-4736. doi:10.1038/onc.2012.616

Author Duijf, P. H. G.
Benezra, R.
Title The cancer biology of whole-chromosome instability
Journal name Oncogene   Check publisher's open access policy
ISSN 0950-9232
Publication date 2013-10-03
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/onc.2012.616
Open Access Status Not Open Access
Volume 32
Issue 40
Start page 4727
End page 4736
Total pages 10
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
One form of chromosome instability (CIN), the recurrent missegregation of whole chromosomes during cell division (W-CIN), leads to aneuploidy. Although W-CIN is a hallmark of most cancers, mutations in genes involved in chromosome segregation are exceedingly rare. We discuss an oncogene-induced mitotic stress model that provides a mechanistic framework to explain this paradox. We also review the tumor-promoting and tumor-suppressing consequences of W-CIN. Importantly, we do this in the context of cancer as a complex systemic disease, rather than as a simple linearly progressing disorder that arises from a single abnormal cell population. Accordingly, we highlight the often neglected effects of W-CIN on key non-cell-autonomous entities, such as the immune system and the tumor microenvironment. Distinct tissue-specific susceptibilities to W-CIN-induced tumorigenesis and the clinical implications of W-CIN are also discussed.
Keyword Whole-chromosome instability
Cancer biology
Oncogene-induced mitotic stress
Non-cell autonomous
Tumor microenvironment
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Diamantina Institute - Open Access Collection
Official 2014 Collection
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Citation counts: TR Web of Science Citation Count  Cited 45 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 48 times in Scopus Article | Citations
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Created: Thu, 31 Oct 2013, 21:41:23 EST by Pascal Duijf on behalf of UQ Diamantina Institute