Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat

Shing, Cecilia M., Peake, Jonathan M., Lim, Chin Leong, Briskey, David, Walsh, Neil P., Fortes, Matthew B., Ahuja, Kiran D. K. and Vitetta, Luis (2013) Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat. European Journal of Applied Physiology, Online First 1: 1-11. doi:10.1007/s00421-013-2748-y

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Author Shing, Cecilia M.
Peake, Jonathan M.
Lim, Chin Leong
Briskey, David
Walsh, Neil P.
Fortes, Matthew B.
Ahuja, Kiran D. K.
Vitetta, Luis
Title Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat
Journal name European Journal of Applied Physiology   Check publisher's open access policy
ISSN 1439-6319
Publication date 2013-10-23
Year available 2014
Sub-type Article (original research)
DOI 10.1007/s00421-013-2748-y
Open Access Status Not yet assessed
Volume Online First
Issue 1
Start page 1
End page 11
Total pages 11
Place of publication Heidelberg, Germany
Publisher Springer
Language eng
Formatted abstract
Purpose This study aimed to investigate the effects of multi-strain probiotics supplementation on gastrointestinal permeability, systemic markers of inflammation and running performance when exercising in the heat.

Methods Ten male runners were randomized to 4 weeks of daily supplementation with a probiotics capsule (45 billion CFU of Lactobacillus, Bifidobacterium and Streptococcus strains) or placebo, separated by a washout period (double-blind, cross-over trial). After each treatment, the runners exercised to fatigue at 80 % of their ventilatory threshold at 35 °C and 40 % humidity. To assess gastrointestinal permeability, runners ingested lactulose and rhamnose before exercise and post-exercise urine was collected to measure sugar concentrations. Venous blood samples were collected before, immediately after and 1 h after exercise, and core temperature was monitored during exercise.

Results Probiotics supplementation significantly increased run time to fatigue (min:s 37:44 ± 2:42 versus 33:00 ± 2:27; P = 0.03, d = 0.54). Average core temperature during exercise was similar between trials (probiotic 38.1 ± 0.2 °C, placebo 38.1 ± 0.1 °C; P = 0.77, d = 0.13). Serum lipopolysaccharide concentration increased post-exercise (P < 0.001), while there was a moderate to large reduction in pre-exercise (d = 0.70) and post-exercise (d = 1.24) concentration following probiotics supplementation. Plasma concentrations of IL-6, IL-10 and IL-1ra increased after exercise (P < 0.01), but there was no significant difference between trials (P > 0.05). There was a small to moderate reduction (d = 0.35) in urine lactulose:rhamnose and a small reduction (d = 0.25) in symptoms of gastrointestinal discomfort following probiotics supplementation (both P = 0.25).

Conclusion Four weeks of supplementation with a multi-strain probiotic increased running time to fatigue in the heat. Further studies are required to elucidate the exact mechanisms for this performance benefit.
Keyword Heat stress
Gastrointestinal integrity
Gastrointestinal tract
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published online: 23 October 2013

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Created: Tue, 29 Oct 2013, 21:23:24 EST by Dr Luis Vitetta on behalf of Medicine - Princess Alexandra Hospital