Primary progressive dynamic aphasia and Parkinsonism: generation, selection and sequencing deficits

Robinson, Gail (2013) Primary progressive dynamic aphasia and Parkinsonism: generation, selection and sequencing deficits. Neuropsychologia, 51 13: 2534-2547. doi:10.1016/j.neuropsychologia.2013.09.038


Author Robinson, Gail
Title Primary progressive dynamic aphasia and Parkinsonism: generation, selection and sequencing deficits
Journal name Neuropsychologia   Check publisher's open access policy
ISSN 0028-3932
1873-3514
Publication date 2013-11-01
Sub-type Article (original research)
DOI 10.1016/j.neuropsychologia.2013.09.038
Volume 51
Issue 13
Start page 2534
End page 2547
Total pages 14
Place of publication Kidlington, Oxford, United Kingdom
Publisher Pergamon
Language eng
Formatted abstract
Highlights
• Dynamic aphasia is reported in a case of NFPA and Parkinson's disease.
• Concurrent deficits in three conceptual preparation mechanisms; selection, generation of ideas and fluent sequencing of novel thoughts.
• Non-verbal generation was impaired – normal generation of novel designs and gestures but high rate of perseveration. Motor movement selection was abnormal.
• Conceptual preparation processes for message generation are organised in a hierarchical or interconnected structure.

MC is the first reported case of dynamic aphasia in the context of non-fluent progressive aphasia and Parkinson's disease. MC's language profile was characterised by the hallmark propositional language impairment despite well-preserved naming, reading, repetition and comprehension skills. The severity of MC's propositional language deficit was comparable to other dynamic aphasic patients. Word and sentence generation performance was severely impaired only when many competing responses were activated by a stimulus. Thus, when a dominant response was available verbal generation was satisfactory. MC also presented with a deficit in idea generation and fluent sequencing of novel thoughts as discourse generation was extremely reduced and perseverative. In addition, non-verbal generation was impaired although dissociations emerged. MC was able to generate novel designs and gestures but his performance was highly perseverative, and his motor movement selection was abnormal, resembling a non-random pattern. MC is the first dynamic aphasic case with concurrent deficits in three mechanisms thought crucial for conceptual preparation processes; namely impaired selection, impaired generation of ideas and impaired fluent sequencing of novel thoughts. The findings are discussed in relation to conceptual preparation processes and their organisation, accounts of dynamic aphasia and the roles of the left inferior frontal and basal ganglia regions in conceptual preparation processes for verbal and non-verbal generation.
Keyword Dynamic aphasia
Conceptual preparation
Selection
Idea generation
Perseveration
Fluent sequencing of novel thought
Non-verbal generation
Parkinson's disease
Progressive aphasia
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
School of Psychology Publications
 
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Created: Tue, 29 Oct 2013, 02:20:11 EST by Gail Robinson on behalf of School of Psychology