High "Normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through Life Study

Mortby, Moyra E., Janke, Andrew L., Anstey, Kaarin J., Sachdev, Perminder S. and Cherbuin, Nicolas (2013) High "Normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through Life Study. PLoS One, 8 9: e73697.1-e73697.9. doi:10.1371/journal.pone.0073697

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Author Mortby, Moyra E.
Janke, Andrew L.
Anstey, Kaarin J.
Sachdev, Perminder S.
Cherbuin, Nicolas
Title High "Normal" blood glucose is associated with decreased brain volume and cognitive performance in the 60s: the PATH through Life Study
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2013-09-01
Year available 2013
Sub-type Article (original research)
DOI 10.1371/journal.pone.0073697
Open Access Status DOI
Volume 8
Issue 9
Start page e73697.1
End page e73697.9
Total pages 9
Place of publication San Francisco, CA, United State
Publisher Public Library of Science
Language eng
Formatted abstract
Context: Type 2 diabetes is associated with cerebral atrophy, cognitive impairment and dementia. We recently showed higher glucose levels in the normal range not to be free of adverse effects and to be associated with greater hippocampal and amygdalar atrophy in older community-dwelling individuals free of diabetes.

Objective: This study aimed to determine whether blood glucose levels in the normal range (<6.1 mmol/L) were associated with cerebral volumes in structures other than the hippocampus and amygdale, and whether these glucose-related regional volumes were associated with cognitive performance.

Design, Setting and Participants: 210 cognitively healthy individuals (68-73 years) without diabetes, glucose intolerance or metabolic syndrome were assessed in the large, community-based Personality and Total Health Through Life (PATH) study.Main

Outcome Measure: Baseline blood glucose levels in the normal range (3.2-6.1 mmol/l) were used to determine regional brain volumes and associated cognitive function at wave 3.

Results: Higher blood glucose levels in the normal range were associated with lower grey/white matter regional volumes in the frontal cortices (middle frontal gyrus, inferior frontal gyrus precentral gyrus). Moreover, identified cerebral regions were associated with poorer cognitive performance and the structure-function associations were gender specific to men.

Conclusion: These findings stress the need to re-evaluate what is considered as healthy blood glucose levels, and consider the role of higher normal blood glucose as a risk factor for cerebral health, cognitive function and dementia. A better lifetime management of blood glucose levels may contribute to improved cerebral and cognitive health in later life and possibly protect against dementia.
Keyword Multidisciplinary Sciences
Science & Technology - Other Topics
MULTIDISCIPLINARY SCIENCES
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 973302
471501
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2014 Collection
Centre for Advanced Imaging Publications
 
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Created: Sun, 27 Oct 2013, 10:15:26 EST by System User on behalf of Centre for Advanced Imaging