The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam

Phan Vu Tra My, Ha Minh Lam, Thompson, Corinne N., Hoang Le Phuc, Pham Thi Ngoc Tuyet, Ha Vinh, Nguyen Van Minh Hoang, PhamVan Minh, Nguyen Thanh Vinh, Cao Thu Thuy, Tran Thi Thu Nga, Nguyen Thi Thu Hau, Nguyen Tran Chinh, Tang Chi Thuong, Ha Manh Tuan, Campbell, James I., Clements, Archie C. A., Farrar, Jeremy, Boni, Maciej F. and Baker, Stephen (2013) The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam. Infection Genetics and Evolution, 18 335-343. doi:10.1016/j.meegid.2013.04.014


Author Phan Vu Tra My
Ha Minh Lam
Thompson, Corinne N.
Hoang Le Phuc
Pham Thi Ngoc Tuyet
Ha Vinh
Nguyen Van Minh Hoang
PhamVan Minh
Nguyen Thanh Vinh
Cao Thu Thuy
Tran Thi Thu Nga
Nguyen Thi Thu Hau
Nguyen Tran Chinh
Tang Chi Thuong
Ha Manh Tuan
Campbell, James I.
Clements, Archie C. A.
Farrar, Jeremy
Boni, Maciej F.
Baker, Stephen
Title The dynamics of GII.4 Norovirus in Ho Chi Minh City, Vietnam
Journal name Infection Genetics and Evolution   Check publisher's open access policy
ISSN 1567-1348
1567-7257
Publication date 2013-08-01
Sub-type Article (original research)
DOI 10.1016/j.meegid.2013.04.014
Volume 18
Start page 335
End page 343
Total pages 9
Place of publication Amsterdam, Netherlands
Publisher Elsevier
Language eng
Abstract Norovirus (NoV) is a major cause of epidemic gastroenteritis in industrialized countries, yet the epidemiological significance of NoV in industrializing countries remains poorly understood. The spatiotemporal distribution of NoV genotypes identified in 2054 enrolled children was investigated between May 2009 and December 2010, in Ho Chi Minh City (HCMC), Vietnam. A total of 315 NoV extracted from stool samples were genotyped and GPS mapped to their source. Genogroup II NoV, particularly GII.4, were predominant, and the GII.4 strains could be subgrouped into GII.4-2006b (Minerva) and GII.4-2010 (New Orleans) variants. There was no spatiotemporal structure among the endemic GII strains; yet a significant spatiotemporal signal corresponding with the novel introduction of GII.4-2010 variant was detected. These data show that NoV GII.4 variants are highly endemic in HCMC and describe a scenario of rapid NoV strain replacement occurring in HCMC in early 2010.
Keyword Norovirus
GII.4
Phylogenetic
Spatial
Temporal
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Public Health Publications
Official 2014 Collection
 
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