The effect of Parkinson'S disease and levodopa on adaptation of anticipatory postural adjustments

Hall, L. M., Brauer, S. G., Horak, F. and Hodges, P. W. (2013) The effect of Parkinson'S disease and levodopa on adaptation of anticipatory postural adjustments. Neuroscience, 250 483-492. doi:10.1016/j.neuroscience.2013.07.006


Author Hall, L. M.
Brauer, S. G.
Horak, F.
Hodges, P. W.
Title The effect of Parkinson'S disease and levodopa on adaptation of anticipatory postural adjustments
Journal name Neuroscience   Check publisher's open access policy
ISSN 0306-4522
1873-7544
Publication date 2013-10-01
Year available 2013
Sub-type Article (original research)
DOI 10.1016/j.neuroscience.2013.07.006
Open Access Status Not yet assessed
Volume 250
Start page 483
End page 492
Total pages 10
Place of publication Oxford, United Kingdom
Publisher Pergamon
Language eng
Abstract Postural support alters anticipatory postural adjustments (APAs). Efficient adaptation to changes in postural support in reactive and centrally initiated postural synergies is impaired in Parkinson's disease (PD). This study examined whether APAs are affected differently by familiar and novel supports in people with PD, ON and OFF levodopa. The effect of PD and levodopa on the ability to immediately adapt APAs to changes in support and refine with practice was also investigated. Fourteen people with PD and 14 healthy control participants performed 20 single rapid leg lift tasks in four support conditions: unsupported, bilateral handgrip (familiar), bite plate (novel) and a combined handgrip + bite plate condition. APAs, identified from force plate data, were characterized by an increase in the vertical ground reaction force under the lifted leg as a result of a shift of weight toward the stance limb. Results showed the ability to incorporate familiar and novel external supports into the postural strategy was preserved in PD. Controls and PD patients in the OFF state further refined the postural strategy with practice as evidenced by changes in amplitude of vertical ground reaction forces and forces applied to support apparatus within conditions between the initial and final trials. In the ON state, people with PD failed to refine the use of postural supports in any condition. The results suggest that immediate postural adaptation is intact in people with PD and unaffected by levodopa administration but the ability to refine postural adaptations with task experience is compromised by dopamine therapy. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.
Formatted abstract
Postural support alters anticipatory postural adjustments (APAs). Efficient adaptation to changes in postural support in reactive and centrally initiated postural synergies is impaired in Parkinson’s disease (PD). This study examined whether APAs are affected differently by familiar and novel supports in people with PD, ON and OFF levodopa. The effect of PD and levodopa on the ability to immediately adapt APAs to changes in support and refine with practice was also investigated. Fourteen people with PD and 14 healthy control participants performed 20 single rapid leg lift tasks in four support conditions: unsupported, bilateral handgrip (familiar), bite plate (novel) and a combined handgrip + bite plate condition. APAs, identified from force plate data, were characterized by an increase in the vertical ground reaction force under the lifted leg as a result of a shift of weight toward the stance limb. Results showed the ability to incorporate familiar and novel external supports into the postural strategy was preserved in PD. Controls and PD patients in the OFF state further refined the postural strategy with practice as evidenced by changes in amplitude of vertical ground reaction forces and forces applied to support apparatus within conditions between the initial and final trials. In the ON state, people with PD failed to refine the use of postural supports in any condition. The results suggest that immediate postural adaptation is intact in people with PD and unaffected by levodopa administration but the ability to refine postural adaptations with task experience is compromised by dopamine therapy.
Keyword Parkinson's disease
Anticipatory postural adjustments
Levodopa
Postural support
Q-Index Code C1
Q-Index Status Confirmed Code
Grant ID 10456017
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: NHMRC reports
Official 2014 Collection
School of Health and Rehabilitation Sciences Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
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